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Mac or MAC may refer to:

Common meanings

Mac (Green Wing), a television character
Mac (It's Always Sunny in Philadelphia), a television character
Mac Gargan, an enemy of Spider-Man
Mac, a character on Foster's Home for Imaginary Friends
Angus "Mac" MacGyver, from the television series MacGyver
Cindy "Mac" Mackenzie, from the TV series Veronica Mars
Lt. Col. Sarah MacKenzie, from the TV series JAG
Dr. Terrence McAfferty, from Robert Muchamore's CHERUB and Henderson's Boys novel series
Mac McAnnally, in The Dresden Files series
Randle McMurphy, in the movie One Flew Over the Cuckoo's Nest
Mac Taylor, from the TV series CSI: NY
Mac, a canine character in the television series Clifford the Big Red Dog
Monster Attack Crew, a fictional pilot squadron in the television series Ultraman Leo
MAC (Mysterious Alien Creature), the titular character in the 1988 film Mac and Me
Mac (Makrand Deendayal Chatpatiya), portrayed by Akshay Kumar in the 2005 Indian comedy film Garam Masala

Mac (film), 1992, directed by and starring John Turturro
Mac (novel), by John MacLean
Mac the Moose, a public statue in Moose Jaw, Saskatchewan, Canada
Mac, a Sports Beanie Baby cardinal produced by Ty, Inc. in 1999
MAC Awards, for achievements in cabaret, comedy, and jazz, administered by the Manhattan Association of Cabarets & Clubs

Marginal abatement cost, in environmental economics
Material adverse change, a provision in mergers and acquisitions contracts and venture financing agreements

MAC Cosmetics, a cosmetics brand, stylized as M•A•C
Mac Para Technology, a Czech aircraft manufacturer
Macerich (NYSE stock symbol MAC), an American real estate investment trust
Manufacture d'armes de Châtellerault, a French state arms manufacturer
Martin's Air Charter, now Martinair, an airline
Medicare Administrative Contractor, a private company contracted to administer Medicare benefits in the US
Military Armament Corporation, former American small arms manufacturer
Morgan Advanced Ceramics, a ceramics manufacturing company
Money Access Card or Money Access Center, a former US ATM network

Mainland Affairs Council, an agency under the Executive Yuan of the Republic of China
Metropolitan Airports Commission, the operator of airports in the Minneapolis-St. Paul area
Military Affairs Commission in China; see Central Military Commission (China)
Military Airlift Command, the predecessor of the Air Mobility Command of the United States Air Force
Mixed Armistice Commissions, a United Nations organization for monitoring Middle East ceasefires
Municipal Assistance Corporation, created by the State of New York in 1975 to deal with New York City's fiscal crisis

Mouvement d'Action Civique, a defunct Belgian far right group
Mouvement Autonome Casamançais (Casamancian Autonomous Movement), a defunct political party in Casamance, Senegal
Mudiad Amddiffyn Cymru, a Welsh organization responsible for several bombing incidents
Muslims Against Crusades, a banned radical Islamist group in the UK

Mac (rapper) (born 1977), American rapper, stage name of McKinley Phipps Jr
MC Mac, member and musician of So Solid Crew
John McCarthy (conductor) (1916–2009), British conductor known as "John Mac" or just "Mac"
Derek McCulloch (1897–1967), British radio broadcaster known as "Uncle Mac"
Ian McCulloch (singer) (born 1959), referred to as "Mac the Mouth" or just "Mac"
Stanley McMurtry (born 1936), British cartoonist with the pen name "Mac"

mac, Birmingham (formerly Midlands Arts Centre), England
Metropolitan Arts Centre, Belfast, UK
Archaeology Museum of Catalonia (Spanish: Museu d'Arqueologia de Catalunya), Spain
Niterói Contemporary Art Museum (Portuguese: Museu de Arte Contemporânea de Niterói), Brazil
Museum of Contemporary Art of Lima (Spanish: Museo de Arte Contemporáneo), Peru

Macau (ISO 3166 code: MAC), an administrative region of China
Macaulay railway station, Melbourne, Australia
UCLA Marina Aquatic Center, a recreational facility in Marina del Rey, California
Macomb station (Amtrac station code: MAC), Illinois, US

MAC (chemotherapy), a chemotherapy regimen of Mitoxantrone and Ara-C
Maximum allowable concentration, a concept related to threshold limit value (TLV)
Membrane attack complex, an immune system function using complement
Microbiota-accessible carbohydrates, a category of carbohydrates consumed by gut microbes
Minimum alveolar concentration, a measure used to compare the strengths of anesthetic vapors
Mitochondrial apoptosis-induced channel, the cytochrome c release pore of apoptotic mitochondria
Monitored anesthesia care, a form of anesthesia with partial awareness
Mycobacterium avium complex, a group of environmental pathogens

Mac (computer), a brand of computers and computer operating systems made by Apple Inc.
- macOS, formerly Mac OS X and OS X, Apple's current operating system for Mac computers
- Classic Mac OS, the original operating system for Apple's Macintosh
- .Mac, now iCloud, a subscription service by Apple
MAC times, metadata containing event times associated with a computer file
Mandatory access control, a type of access control in computer security
Maximum activate count, a parameter associated with the LPDDR4 memory's TRR feature
Medium access control or Media Access Control, a sublayer of the Data Link layer
- MAC address, a unique identifier assigned to a network interface controller
Message authentication code, used to authenticate a message in cryptography
Migration Authorisation Code, used when switching Internet service providers in the UK
Multiplexed Analogue Components, a proposed satellite television transmission standard
Multiply–accumulate operation (MAC), or multiplier–accumulator, in digital signal processing
.mac, a file extension for macros in Agilent ChemStation software

Merchant aircraft carrier, used during World War II by Britain and the Netherlands
Mission Assurance Category, a US Department of Defense engineering designation
Modern Army Combatives, a hand-to-hand combat training regimen

Maranhão Atlético Clube, a Brazilian association football club
Marília Atlético Clube, a Brazilian association football club
Missouri Athletic Club, a traditional gentlemen's and athletic club in downtown St. Louis, Missouri
Multnomah Athletic Club, a private athletic club in Oregon

Mid-American Conference, an NCAA Division I (Football Bowl Subdivision) sports conference
Mid-Atlantic Rifle Conference, an NCAA rifle-only conference
Middle Atlantic Conferences, an umbrella organization for three NCAA Division III sports conferences
- Middle Atlantic Conference, one of these three