MODY 4

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "MODY 4" – news · newspapers · books · scholar · JSTOR (March 2018) (Learn how and when to remove this message)

MODY 4
Specialty	Endocrinology

MODY 4 or PDX1-MODY is a form of maturity onset diabetes of the young.

MODY 4 arises from mutations of the PDX1 homeobox gene on chromosome 13. Pdx-1 is a transcription factor vital to the development of the embryonic pancreas. Even in adults it continues to play a role in the regulation and expression of genes for insulin, GLUT2, glucokinase, and somatostatin.

MODY 4 is so rare that only a single family has been well-studied. A child born with pancreatic agenesis (absence of the pancreas) was found to be homozygous for Pdx-1 mutations. A number of older relatives who were heterozygous had mild hyperglycemia or diabetes. None were severely insulin-deficient and all were controlled with either diet or oral hypoglycemic agents.

References

External links

v t e Disease of the pancreas and glucose metabolism
Diabetes	Types type 1 type 2 gestational MODY 1 2 3 4 5 6 Complications See Template:Diabetes
Abnormal blood glucose levels	Hyperglycemia Oxyhyperglycemia Hypoglycemia Whipple's triad
Insulin disorders	Insulin resistance Hyperinsulinism Congenital hyperinsulinism Rabson–Mendenhall syndrome
Other pancreatic disorders and conditions	Pancreatic beta cell function Insulinoma Insulitis

Genetic disorders relating to deficiencies of transcription factor or coregulators

(1) Basic domains

1.2	Feingold syndrome Saethre–Chotzen syndrome
1.3	Tietz syndrome

(2) Zinc finger
DNA-binding domains

2.1	(Intracellular receptor): Thyroid hormone resistance Androgen insensitivity syndrome PAIS MAIS CAIS Kennedy's disease PHA1AD pseudohypoaldosteronism Estrogen insensitivity syndrome X-linked adrenal hypoplasia congenita MODY 1 Familial partial lipodystrophy 3 SF1 XY gonadal dysgenesis
2.2	Barakat syndrome Tricho–rhino–phalangeal syndrome
2.3	Greig cephalopolysyndactyly syndrome/Pallister–Hall syndrome Denys–Drash syndrome Duane-radial ray syndrome MODY 7 MRX 89 Townes–Brocks syndrome Acrocallosal syndrome Myotonic dystrophy 2
2.5	Autoimmune polyendocrine syndrome type 1

(3) Helix-turn-helix domains

3.1	ARX Ohtahara syndrome Lissencephaly X2 MNX1 Currarino syndrome HOXD13 SPD1 synpolydactyly PDX1 MODY 4 LMX1B Nail–patella syndrome MSX1 Tooth and nail syndrome OFC5 PITX2 Axenfeld syndrome 1 POU4F3 DFNA15 POU3F4 DFNX2 ZEB1 Posterior polymorphous corneal dystrophy Fuchs' dystrophy 3 ZEB2 Mowat–Wilson syndrome
3.2	PAX2 Papillorenal syndrome PAX3 Waardenburg syndrome 1&3 PAX4 MODY 9 PAX6 Gillespie syndrome Coloboma of optic nerve PAX8 Congenital hypothyroidism 2 PAX9 STHAG3
3.3	FOXC1 Axenfeld syndrome 3 Iridogoniodysgenesis, dominant type FOXC2 Lymphedema–distichiasis syndrome FOXE1 Bamforth–Lazarus syndrome FOXE3 Anterior segment mesenchymal dysgenesis FOXF1 ACD/MPV FOXI1 Enlarged vestibular aqueduct FOXL2 Premature ovarian failure 3 FOXP3 IPEX
3.5	IRF6 Van der Woude syndrome Popliteal pterygium syndrome

(4) β-Scaffold factors
with minor groove contacts

4.2	Hyperimmunoglobulin E syndrome
4.3	Holt–Oram syndrome Li–Fraumeni syndrome Ulnar–mammary syndrome
4.7	Campomelic dysplasia MODY 3 MODY 5 SF1 SRY XY gonadal dysgenesis Premature ovarian failure 7 SOX10 Waardenburg syndrome 4c Yemenite deaf-blind hypopigmentation syndrome
4.11	Cleidocranial dysostosis

(0) Other transcription factors

0.6	Kabuki syndrome

Ungrouped

Transcription coregulators

Coactivator:	CREBBP Rubinstein–Taybi syndrome
Corepressor:	HR (Atrichia with papular lesions)

^[1]

This article about an endocrine, nutritional, or metabolic disease is a stub. You can help Wikipedia by expanding it.

^ Stoffers, Doris A.; Ferrer, Jorge; L. Clarke, William; Habener, Joel (1997). "Early-onset type-II diabetes mellitus (MODY4) linked to IPF1". Nature Genetics. 17: 138–139. doi:10.1038/ng1097-138.

Read other articles:

Fatima Jinnah Medical University

Public medical university in Lahore, Pakistan Fatima Jinnah Medical Universityجامعہ طبی فاطمہ جناحTypePublic universityEstablishedMarch 1948 (1948-03)FounderShujaat AliVice-ChancellorProf. Khalid Masud GondalAcademic staff300Students1500LocationLahore, Punjab, PakistanColorsUpsdell Red AffiliationsHigher Education Commission of PakistanSir Ganga Ram HospitalPakistan Medical & Dental CouncilWebsitewww.fjmu.edu.pk Fatima Jinnah Medical University (Urdu: جا...

The Witches (novel)

1983 children's book by Roald Dahl The Witches First edition coverAuthorRoald DahlIllustratorQuentin BlakeCountryUnited KingdomGenreChildren's fantasyDark fantasyPublisherJonathan CapePublication date27 October 1983Media typePrintPages208AwardsWhitbread Book Award (1983)ISBN978-1101662977 The Witches is a 1983 children's novel by British author Roald Dahl. A dark fantasy, the story is set partly in Norway and partly in England, and features the experiences of a young English boy and his ...

الدوري الأردني 1991–92

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (يونيو 2019) هذه المقالة تحتاج للمزيد من الوصلات للمقالات الأخرى للمساعدة في ترابط مقالات الموسوعة. فضلًا ساعد في تحسي...

Rizvan Kurbanov

Russian politician In this name that follows Eastern Slavic naming customs, the patronymic is Daniyalovich and the family name is Kurbanov. Rizvan KurbanovРизван КурбановDeputy of the 8th State DumaIncumbentAssumed office 19 September 2021Deputy of the 7th State DumaIn office5 October 2016 – 12 October 2021Deputy of the 6th State DumaIn office21 December 2011 – 5 October 2016 Personal detailsBorn (1961-01-03) 3 January 1961 (age 63)Buynaksk, Da...

Nehebkau

This article is about the Egyptian deity. It is not to be confused with Neheb, Nehemiah or Nehmetawy. Ancient Egyptian deity NehebkauIllustration of Nehebkau based on depictions in papyriOther namesNehebu-KauVenerated inMiddle Kingdom and New KingdomAbodeHeliopolisGenderMaleParentsSerket or Geb and RenenutetConsortNehmetawy Part of a series onAncient Egyptian religion Beliefs Afterlife Cosmology Duat Ma'at Mythology Index Numerology Philosophy Soul Practices Funerals Offerings: Offering formu...

Paper

Material for writing, printing, etc. For other uses, see Paper (disambiguation). PaperPaper products: book, toilet paper, ruled paper, carton, egg boxMaterial typeThin materialPhysical propertiesDensity (ρ)From 10 gsm to 3000 gsm PaperPaper in Traditional (top) and Simplified (bottom) Chinese charactersTraditional Chinese紙Simplified Chinese纸TranscriptionsStandard MandarinHanyu PinyinzhǐIPA[ʈʂɨ̀]WuShanghaineseRomanizationtsy5Yue: CantoneseYale RomanizationjíJyutpingzi2South...

Minh Hương

Group of ethnic Chinese You can help expand this article with text translated from the corresponding article in Chinese. (December 2018) Click [show] for important translation instructions. View a machine-translated version of the Chinese article. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated t...

History of the Pittsburgh Steelers

Sports team history The Pittsburgh Steelers are an American football franchise representing Pittsburgh. They are the seventh-oldest club in the National Football League (NFL), which they joined in 1933.[1] The only surviving NFL teams with a longer history are the Chicago Bears, Arizona Cardinals (then the Chicago Cardinals), Detroit Lions (then the Portsmouth Spartans), Green Bay Packers, New York Giants, and Washington Commanders (then the Boston Redskins). The Philadelphia Eagles j...

Film drammatico

Questa voce sull'argomento generi cinematografici è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Via col vento è un dramma romantico. Un film drammatico è un genere di film che si basa sullo sviluppo dei personaggi, dell'interazione tra essi e che tratta temi di impatto emotivo[1]. Indice 1 Descrizione 2 Note 3 Altri progetti 4 Collegamenti esterni Descrizione La definizione del genere è co...

大字 (数字)

この項目には、一部のコンピュータや閲覧ソフトで表示できない文字が含まれています（詳細）。数字の大字（だいじ）は、漢数字の一種。通常用いる単純な字形の漢数字（小字）の代わりに同じ音の別の漢字を用いるものである。概要壱万円日本銀行券（「壱」が大字）弐千円日本銀行券（「弐」が大字）漢数字には「一」「二」「三」と続く小字と、「壱」「�...

Seol Ye-eun

South Korean curler Seol Ye-eunCurlerBorn (1996-08-26) August 26, 1996 (age 27)Seoul, South KoreaTeamCurling clubUijeongbu CC, UijeongbuSkipGim Eun-jiThirdKim Min-jiSecondKim Su-jiLeadSeol Ye-eunAlternateSeol Ye-jiCurling career Member Association South KoreaWorld Championshipappearances1 (2024)Pacific-Asia Championshipappearances1 (2019)Pan Continental Championshipappearances1 (2023)Grand Slam victories1 (2023 National) Medal record Representing South Korea World Championship...

1997–98 NCAA Division I men's basketball season

Basketball season 1997–98 NCAA Division I men's basketball seasonPreseason AP No. 1ArizonaRegular seasonNovember 1997 –March 1998NCAA Tournament1998Tournament datesMarch 12 – March 30, 1998National ChampionshipAlamodomeSan Antonio, TexasNCAA ChampionsKentucky WildcatsOther championsMinnesota Golden Gophers (NIT)Player of the Year(Naismith, Wooden)Antawn Jamison, North Carolina← 1996–97 1998–99 → The 1997–98 NCAA Division I men's basketball season conc...

Meena Sharma

Meena SharmaBornc.1984[1]NationalityIndianOccupation(s)Journalist and TV anchorKnown forinvestigative journalism Dr. Meena Sharma (c.1984 - ) is an Indian journalist who was awarded the Nari Shakti Puraskar in 2016. She has identified scandals of children who did not look after their elderly parents and the large number of abortions that were taking place of pregnancies that were predicted to deliver a female child. Life She has been an editor at Patrika TV and as an anchor for Z...

بوغد خانات منغوليا

بوغد خانات منغوليا بوغد خانات منغولياالعلم بوغد خانات منغولياالشعار النشيد: الأرض والسكان عاصمة أولان باتور اللغة الرسمية المغولية التعداد السكاني 542504 (1915) الحكم نظام الحكم خانية، وثيقراطية، وملكية، وملكية انتخابية، وتبعية التأسيس وال�...

Чхиллар, Мануши

Мануши Чхиллархинди मानुषी छिल्लर Дата рождения 14 мая 1997(1997-05-14)[1][2] (27 лет) Место рождения Рохтак, Харьяна, Индия[3] Гражданство Индия Род деятельности участница конкурса красоты, актриса, киноактриса Внешний вид Рост 1,75 м Цвет волос коричневы�...

Lac operon

Set genes encoding proteins and enzymes for lactose metabolism The lactose operon (lac operon) is an operon required for the transport and metabolism of lactose in E. coli and many other enteric bacteria. Although glucose is the preferred carbon source for most enteric bacteria, the lac operon allows for the effective digestion of lactose when glucose is not available through the activity of β-galactosidase.[1] Gene regulation of the lac operon was the first genetic regulatory mechan...

Maja Herman Sekulić

Yugoslav poet, novelist, essayist and translator This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) The topic of this article may not meet Wikipedia's notability guideline for biographies. Please help to demonstrate the notability of the topic by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notabi...

Jens Peick

German politician Portrait of Jens Peick Jens Peick (born 16 August 1981 in Castrop-Rauxel) is a German trade unionist and SPD politician. He is a member of the German Bundestag and chairman of the SPD Dortmund. Early life and career Peick was born 1981 in the West German town of Castrop-Rauxel[1] and grew up in the Kirchlinde district of Dortmund. His father was a locksmith in the chemical plant and his mother worked in a curtain store in the Lütgendortmund quarter. After attending ...

Innsbruck Festival of Early Music

Ambras Castle, one of the festival's main concert venues The Innsbruck Festival of Early Music (German: Innsbrucker Festwochen der Alten Musik) is a festival of historically informed performances of music from the late Renaissance, Baroque and early Classical periods which takes place annually in Innsbruck, Austria. It was founded in 1976.[1] History The festival had its roots in 1963 when the Innsbruck musician Otto Ulf (1907–1993) organized a concert at the Ambras Castle to celebr...

Ed Wachter

Questa voce sugli argomenti allenatori di pallacanestro statunitensi e cestisti statunitensi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti dei progetti di riferimento 1, 2. Ed WachterWatcher in una figurina del 1933Nazionalità Stati Uniti Pallacanestro RuoloCentro Hall of fameNaismith Hall of Fame (1961) CarrieraSquadre di club HaverhillCompany E Schenectady Troy Trojans Carriera da allenatore 1916-1917 AS G...