1IAF
4224
17287
ENSG00000112818
ENSMUSG00000023914
Q16819
P28825
NM_005588
NM_008585
NP_005579
NP_032611
Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene.[5][6] The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.[7]
The meprin alpha subunit product of the MEP1A gene is processed in the endoplasmic reticulum during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing MEP1B, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric meprin A.
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