MAGI2

MAGI2
Identifiers
Aliases	MAGI2, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, membrane associated guanylate kinase, WW and PDZ domain containing 2, NPHS15
External IDs	OMIM: 606382; MGI: 1354953; GeneCards: MAGI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UEP, 1UEQ, 1UEW, 1UJV, 1WFV
Gene location (Human)
Chr.	Chromosome 7 (human)
End	79,453,667 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	20,909,790 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; Brodmann area 23; ; middle temporal gyrus; ; glomerulus; ; metanephric glomerulus; ; Brodmann area 46; ; parietal lobe; ; entorhinal cortex; ; postcentral gyrus;
	Top expressed in
	Rostral migratory stream; ; primary motor cortex; ; cingulate gyrus; ; substantia nigra; ; Region I of hippocampus proper; ; nucleus accumbens; ; globus pallidus; ; primary visual cortex; ; sciatic nerve; ; arcuate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; SMAD binding; phosphatase binding; beta-1 adrenergic receptor binding; molecular adaptor activity; type II activin receptor binding; signaling receptor complex adaptor activity; protein binding; activin receptor binding; kinase activity;
Cellular component	late endosome; cytoplasm; synapse; cell junction; nucleus; neuron projection; postsynaptic density; membrane; dendrite; perinuclear region of cytoplasm; slit diaphragm; bicellular tight junction; plasma membrane; endosome; protein-containing complex; cell-cell junction;
Biological process	receptor clustering; negative regulation of cell population proliferation; positive regulation of neuron projection development; neuroligin clustering involved in postsynaptic membrane assembly; signal transduction; negative regulation of activin receptor signaling pathway; nerve growth factor signaling pathway; planar cell polarity pathway involved in axis elongation; SMAD protein signal transduction; positive regulation of receptor internalization; protein heterooligomerization; negative regulation of protein kinase B signaling; nervous system development; glomerular visceral epithelial cell development; positive regulation of synaptic vesicle clustering; cellular response to nerve growth factor stimulus; positive regulation of phosphoprotein phosphatase activity; negative regulation of cell migration; positive regulation of signal transduction; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9863
	50791
	ENSG00000187391
	ENSMUSG00000040003
	Q86UL8
	Q9WVQ1
	NM_001301128; NM_012301
	NM_001170745; NM_001170746; NM_015823
	NP_001288057; NP_036433
	NP_001164216; NP_001164217; NP_056638
	Wikidata
View/Edit Human	View/Edit Mouse

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.^[7]

Interactions

MAGI2 has been shown to interact with ATN1^[8] and PTEN (gene).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187391 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040003 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, et al. (March 2000). "Identification and characterization of a PDZ protein that interacts with activin type II receptors". The Journal of Biological Chemistry. 275 (8): 5485–5492. doi:10.1074/jbc.275.8.5485. PMID 10681527.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ ^a ^b "Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2".
^ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, et al. (June 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Molecular and Cellular Neurosciences. 11 (3): 149–160. doi:10.1006/mcne.1998.0677. PMID 9647693. S2CID 20003277.

Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Ide N, Hata Y, Deguchi M, Hirao K, Yao I, Takai Y (March 1999). "Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin". Biochemical and Biophysical Research Communications. 256 (3): 456–461. doi:10.1006/bbrc.1999.0364. PMID 10080919.
Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, et al. (April 2000). "Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2". Proceedings of the National Academy of Sciences of the United States of America. 97 (8): 4233–4238. Bibcode:2000PNAS...97.4233W. doi:10.1073/pnas.97.8.4233. PMC 18208. PMID 10760291.
Xu J, Paquet M, Lau AG, Wood JD, Ross CA, Hall RA (November 2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95". The Journal of Biological Chemistry. 276 (44): 41310–41317. doi:10.1074/jbc.M107480200. PMID 11526121.
Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR (December 2001). "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex". The Journal of Biological Chemistry. 276 (52): 48627–48630. doi:10.1074/jbc.C100556200. PMID 11707428.
Nishimura W, Yao I, Iida J, Tanaka N, Hata Y (February 2002). "Interaction of synaptic scaffolding molecule and Beta -catenin". The Journal of Neuroscience. 22 (3): 757–765. doi:10.1523/JNEUROSCI.22-03-00757.2002. PMC 6758496. PMID 11826105.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Yap CC, Muto Y, Kishida H, Hashikawa T, Yano R (February 2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein". Biochemical and Biophysical Research Communications. 301 (4): 1122–1128. doi:10.1016/S0006-291X(03)00070-6. PMID 12589829.
Evgrafov OV, Mersiyanova I, Irobi J, Van Den Bosch L, Dierick I, Leung CL, et al. (June 2004). "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy". Nature Genetics. 36 (6): 602–606. doi:10.1038/ng1354. PMID 15122254.
Franklin JL, Yoshiura K, Dempsey PJ, Bogatcheva G, Jeyakumar L, Meise KS, et al. (February 2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein". Experimental Cell Research. 303 (2): 457–470. doi:10.1016/j.yexcr.2004.10.007. PMID 15652357.
Hu Y, Li Z, Guo L, Wang L, Zhang L, Cai X, et al. (November 2007). "MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells". Archives of Biochemistry and Biophysics. 467 (1): 1–9. doi:10.1016/j.abb.2007.07.027. PMID 17880912.