The M21 bus route begins at Spring Street and Hudson Street in the West Village. Eastbound buses use Sixth Avenue to access Houston Street, whereas westbound buses use Washington Street to access the terminus. The M21 stays on Houston Street until Columbia Street. Eastbound buses continue to FDR Drive, and use the service road to access Grand Street, where they terminate. Westbound buses then use Lewis Street, Delancey Street, and Columbia Street to access Houston St, where they head back to the West Side.[2][3] During the afternoon rush hour, M21 buses short turn at Sixth Avenue instead of terminating at Washington Street.
A 2006 OrionVII OG HEV (6743) on the M21 at Houston/Varick Streets in May 2018.
Due to the 2010 budget crisis, the M21 which ran to 29th Street via Avenue C and weekend service was discontinued on June 27, 2010, in conjunction with an extension to its current terminus at Grand Street and FDR Drive.[4] Weekend service was restored on January 6, 2013.[5] On January 3, 2022, the M21 had its western terminus during PM rush hours truncated to 6th Avenue due to rush hour traffic on Varick Street approaching the Holland Tunnel.[6][7]
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