Low-intensity pulsed ultrasound

Low-intensity pulsed ultrasound

Low-intensity pulsed ultrasound (LIPUS) is a technology that can be used for therapeutic purposes. It exploits low intensity and pulsed mechanical waves in order to induce regenerative and anti-inflammatory effects on biological tissues, such as bone,[1] cartilage, and tendon.[2] Even if the real mechanism underlying its effectiveness has not been understood yet, it is plausible that the treatment relies on non-thermal phenomena, such as microbubbles and microjets induced by cavitation, acoustic streaming, and mechanical stimulation.[3][2]

Technique

LIPUS uses generally 1.5 MHz frequency pulses, with a pulse width of 200 μs, repeated at 1 kHz, at a spatial average and temporal average intensity of 30 mW/cm2.[4]

Medical uses

Starting around the 1950s this technology was being used as a form of physical therapy for ailments such as tendinitis.[5]

As of 2009 research for the use of LIPUS to treat soft tissue injuries were in the early stages.[4] As of 2012 it was being studied for dental problems.[6]

Low intensity pulsed ultrasound has been proposed as a therapy to support bone healing after fractures,[1] osteomies, or delayed healing. A 2017 review, however, found no trustworthy evidence for the use of low intensity pulsed ultrasound for bone healing, mostly based on the large pragmatic randomized controlled trial published in 2016.[7][8] An associated guideline issued a strong recommendation against its use in bone healing.[9] Evidence as of 2023 was insufficient to justify its use to prevent non healing of bone fractures.[10] Tentative evidence supports better healing with the use of the system in long bones that have not healed after three months.[11] Some reviews suggested inconclusive evidence of benefit.[12][10] One industry supported meta-analysis suggested it as a potential alternative to surgery for established nonunions.[13] Most studies suggesting benefit were funded by manufacturers of ultrasound devices.[7]

In 2018, a study published in the journal Brain Stimulation, reported that experiments on mice showed that whole-brain LIPUS therapy markedly improved cognitive dysfunctions without serious side effects by enhancing specific cells related to dementia's pathology. Clinical trials are underway.[14]

In vitro experiments have confirmed the LIPUS capability to regulate cell proliferation and differentiation as well as the opening of cell membrane channels.[2]

References

  1. ^ a b El-Bialy, Tarek; Tanaka, Eiji; Aizenbud, Dror (June 25, 2018). "Mechanism of LIPUS on Dentofacial Bioengineering". Therapeutic Ultrasound in Dentistry: Applications for Dentofacial Repair, Regeneration, and Tissue Engineering. Springer. ISBN 9783319663234.
  2. ^ a b c Jiang, Xiaoxue; Savchenko, Oleksandra; Li, Yufeng; Qi, Shiang; Yang, Tianlin; Zhang, Wei; Chen, Jie (2018). "A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications". IEEE Transactions on Biomedical Engineering. 66 (10): 2704–2718. doi:10.1109/TBME.2018.2889669. ISSN 0018-9294. PMID 30596564. S2CID 58581708.
  3. ^ Lin, Guiting; Reed-Maldonado, Amanda; Lin, Maofan; Xin, Zhongcheng; Lue, Tom (2016). "Effects and Mechanisms of Low-Intensity Pulsed Ultrasound for Chronic Prostatitis and Chronic Pelvic Pain Syndrome". International Journal of Molecular Sciences. 17 (7): 1057. doi:10.3390/ijms17071057. ISSN 1422-0067. PMC 4964433. PMID 27376284.
  4. ^ a b Khanna, A; Nelmes, RT; Gougoulias, N; Maffulli, N; Gray, J (2009). "The effects of LIPUS on soft-tissue healing: a review of literature". British Medical Bulletin. 89: 169–82. doi:10.1093/bmb/ldn040. PMID 19011263.
  5. ^ Miller, Douglas; Smith, Nadine; Bailey, Michael; Czarnota, Gregory; Hynynen, Kullervo; Makin, Inder (April 2012). "Overview of Therapeutic Ultrasound Applications and Safety Considerations". Journal of Ultrasound in Medicine. 31 (4): 623–634. doi:10.7863/jum.2012.31.4.623. ISSN 0278-4297. PMC 3810427. PMID 22441920.
  6. ^ Rego, E. B. (2012). "Current Status of Low Intensity Pulsed Ultrasound for Dental Purposes". The Open Dentistry Journal. 6: 220–5. doi:10.2174/1874210601206010220. PMC 3547311. PMID 23341848.
  7. ^ a b Schandelmaier, Stefan; Kaushal, Alka; Lytvyn, Lyubov; Heels-Ansdell, Diane; Siemieniuk, Reed A. C.; Agoritsas, Thomas; Guyatt, Gordon H.; Vandvik, Per O.; Couban, Rachel; Mollon, Brent; Busse, Jason W. (February 22, 2017). "Low intensity pulsed ultrasound for bone healing: systematic review of randomized controlled trials". BMJ. 356: j656. doi:10.1136/bmj.j656. ISSN 1756-1833. PMC 5484179. PMID 28348110.
  8. ^ Group, TRUST Investigators writing; Busse, Jason W.; Bhandari, Mohit; Einhorn, Thomas A.; Schemitsch, Emil; Heckman, James D.; Tornetta, Paul; Leung, Kwok-Sui; Heels-Ansdell, Diane; Makosso-Kallyth, Sun; Rocca, Gregory J. Della (October 25, 2016). "Re-evaluation of low intensity pulsed ultrasound in treatment of tibial fractures (TRUST): randomized clinical trial". BMJ. 355: i5351. doi:10.1136/bmj.i5351. ISSN 1756-1833. PMC 5080447. PMID 27797787. {{cite journal}}: |last1= has generic name (help)
  9. ^ Poolman, RW; Agoritsas, T; Siemieniuk, RA; Harris, IA; Schipper, IB; Mollon, B; Smith, M; Albin, A; Nador, S; Sasges, W; Schandelmaier, S; Lytvyn, L; Kuijpers, T; van Beers, LW; Verhofstad, MH; Vandvik, PO (February 21, 2017). "Low intensity pulsed ultrasound (LIPUS) for bone healing: a clinical practice guideline". BMJ (Clinical Research Ed.). 356: j576. doi:10.1136/bmj.j576. hdl:1765/98256. PMID 28228381.
  10. ^ a b Searle, Henry Kc; Lewis, Sharon R.; Coyle, Conor; Welch, Matthew; Griffin, Xavier L. (March 3, 2023). "Ultrasound and shockwave therapy for acute fractures in adults". The Cochrane Database of Systematic Reviews. 2023 (3): CD008579. doi:10.1002/14651858.CD008579.pub4. ISSN 1469-493X. PMC 9983300. PMID 36866917.
  11. ^ Higgins, A; Glover, M; Yang, Y; Bayliss, S; Meads, C; Lord, J (October 2014). "EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance". Applied Health Economics and Health Policy. 12 (5): 477–84. doi:10.1007/s40258-014-0117-6. PMC 4175405. PMID 25060830.
  12. ^ Lou, S.; Lv, H.; Li, Z.; Zhang, L.; Tang, P (September 1, 2017). "The effects of low-intensity pulsed ultrasound on fresh fracture: A meta-analysis". Medicine. 96 (39): e8181. doi:10.1097/MD.0000000000008181. PMC 5626319. PMID 28953676.
  13. ^ Leighton, R.; Watson, J.T; Giannoudis, P.; Papakostidis, C.; Harrison, A.; Steen, R.G. (May 2017). "Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis". Injury. 48 (7): 1339–1347. doi:10.1016/j.injury.2017.05.016. PMID 28532896.
  14. ^ "Whole-brain LIPUS therapy improves cognitive dysfunction in mice simulating dementia, Alzheimer's". News-Medical.net. July 20, 2018. Retrieved July 20, 2018.

Read other articles:

Scylla paramamosain

Scylla paramamosain Kepiting bakau hijau, Scylla paramamosaindari Segarajaya, Tarumajaya, Bekasi Klasifikasi ilmiah Kerajaan: Animalia Filum: Arthropoda Subfilum: Crustacea Kelas: Malacostraca Ordo: Decapoda Infraordo: Brachyura Famili: Portunidae Genus: Scylla Spesies: S. paramamosain Nama binomial Scylla paramamosainEstampador, 1949 Sinonim Scylla serrata var. paramamosain Estampador, 1949[1] (basionym) Scylla oceanica Serène, 1952 Scylla serrata Holthuis, 1978 Scylla paramam...

 

Nerve fascicle

Bundle of funiculi (small bundles of axons) in the peripheral nervous system Nerve fascicleNerve structureIdentifiersTA98A14.1.00.012TA26157FMA12235Anatomical terminology[edit on Wikidata]Not to be confused with Muscle fascicle. A nerve fascicle is a bundle of nerve fibers belonging to a nerve in the peripheral nervous system.[1] A nerve fascicle is also called a fasciculus,[2] as is a nerve tract in the central nervous system. A nerve fascicle is enclosed by perineurium, ...

 

Branjangan-padang

Branjangan-padang adalah burung padang rumput Dunia Baru yang termasuk dalam genera Sturnella dan Leistes . Kelompok ini mencakup tujuh spesies burung padang rumput yang sebagian besar merupakan pemakan serangga . Pada semua spesies, jantan setidaknya memiliki punggung berwarna hitam atau coklat dan bagian bawah berwarna merah atau kuning. Daftar spesies Jalak-padang dada-merah ( Leistes militaris ) Genus leistes Branjangan-padang dada-merah (sebelumnya burung hitam dada merah), Leistes milit...

وكالة أنباء فارس

  وكالة أنباء فارس وكالة أنباء فارس‌ وكالة أنباء فارس‌ الاختصار وكالة الأنباء الفارسية البلد إيران  المقر الرئيسي طهران  تاريخ التأسيس 2003؛ منذ 21 سنوات (2003) النوع وكالة إخبارية ar.farsnews.ir ar.farsnews.ir الموقع الرسمي  · farsnews.ir (بـالفارسية) · english.farsnews.ir (ب...

 

Canakya

CanakyaTokoh Inspirasi ChanakyaLahir350 SM[1][2]Meninggal275 SM[1][2]PataliputraNama lainKauṭilya, VishnuguptaAlmamaterTaxilaPekerjaanProfessor; Pengawas Chandragupta MauryaDikenal atasPendiri Kerajaan MauryaKarya terkenalArthashastra, Chanakya NitiOrang tuaChanake (bapak) Cānakya (Dewanagari: चाणक्य; ,IAST: Cāṇakya,; Tamil: சாணக்கியன்; IAST: Cāṇakiyan) (sekitar 350–275 SM) adalah seorang penasihat...

 

Andronikos III Palaiologos

Andronikos III PalaiologosKaisar Romawi TimurAndronikos III Palaiologos.Stuttgart, Württembergische LandesbibliothekBerkuasa1328 – 15 Juni 1341PendahuluAndronikos II PalaiologosPenerusIoannes V PalaiologosKelahiran25 Maret 1297Konstantinopel, Kekaisaran Romawi TimurKematian15 Juni 1341 (usia 44)Konstantinopel, Kekaisaran Romawi TimurWangsaWangsa PalaiologosNama lengkapAndronikos III PalaiologosYunani: Ανδρόνικος Γ' ΠαλαιολόγοςAyahMichael IX PalaiologosIbuRita dari...

George Kingsmill

Canadian administrator (1808-1852) George KingsmillHigh Constable of theToronto Police DepartmentIn office1835–1835Preceded byWilliam HigginsSucceeded byJames StittIn office1837–1846Preceded byJames StittSucceeded bySamuel Sherwood Personal detailsBorn1808Queen's County, IrelandDied1852 (aged 43–44)Galt, Canada WestOccupationSoldier, merchant George Kingsmill (1808–1852) was the High Constable of Toronto in 1835 and from 1837 to 1846. Kingsmill was born in Queen's County, Ire...

 

KFMT-FM

For other stations that have used the KFMT callsign, see KFMT (disambiguation). Radio station in Fremont, NebraskaKFMT-FMFremont, NebraskaBroadcast areaFremont, NebraskaFrequency105.5 MHzBrandingMix 105.5ProgrammingFormatAdult contemporaryOwnershipOwnerSteven W. Seline(Walnut Radio, LLC)Sister stationsKHUBHistoryFirst air date1987Call sign meaningFreMonTTechnical informationFacility ID34549ClassAERP1,200 wattsHAAT137 meters (449 ft)Transmitter coordinates41°24′40.00″N 96°31′53.00...

 

Admiral Schofield

Questa voce sull'argomento cestisti statunitensi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Admiral Schofield Admiral Schofield con la maglia dei Washington Wizards Nazionalità  Stati Uniti Altezza 196 cm Peso 109 kg Pallacanestro Ruolo Ala piccola Squadra  Orlando Magic Osceola Magic Carriera Giovanili Zion-Benton Township High School2015-2019 Tenn. Volunteers Squadre di club...

Spartacus

Thracian gladiator who led a slave revolt For other uses, see Spartacus (disambiguation). Not to be confused with Spartocus or Sportacus. SpartacusThe Death of Spartacus by Hermann Vogel (1882)Bornc. 103 BCNear the Strymon river in present-day BulgariaDied71 BC (aged 32)Near Sele River in Lucania, Italy[1]Years of service73–71 BCCommands heldRebel slave armyBattles/warsThird Servile War Spartacus (Greek: Σπάρτακος, translit. Spártakos; Latin: Spartacus...

 

Kirchdorf an der Amper

Kirchdorf a.d.Amper Lambang kebesaranLetak Kirchdorf a.d.Amper di Freising NegaraJermanNegara bagianBayernWilayahOberbayernKreisFreisingPemerintahan • MayorKonrad SpringerLuas • Total32,988 km2 (12,737 sq mi)Ketinggian440 m (1,440 ft)Populasi (2013-12-31)[1] • Total2.903 • Kepadatan0,088/km2 (0,23/sq mi)Zona waktuWET/WMPET (UTC+1/+2)Kode pos85414Kode area telepon08166Pelat kendaraanFSSitus webwww.gemein...

 

David Destorme

Belgian footballer This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.Find sources: David Destorme – news · newspapers · books · scholar · JSTOR (February 2014) (Learn how and when to remove this message) David ...

Vistula Land

This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (July 2024) (Learn how and when to remove this message) 1867–1915 name for Congress Poland Vistula Land Привислинский край (Russian) Kraj Nadwiślański (Polish) Krai of the Russian Empire1867–1915 Flag Coat of arms Russian map of Vistula Land from 1896CapitalWarsawHistory •&...

 

Royal Australian Army Chaplains' Department

Royal Australian Army Chaplains' DepartmentActive1913 – presentCountry AustraliaBranchArmyTypeCorpsRoleMilitary chaplaincyNickname(s)PadreMotto(s)In this Sign ConquerCommandersDirector General ChaplaincyPastor Darren Jaensch AM (Protestant — Lutheran)Catholic Principal ChaplainMonsignor Glynn Murphy OAMAnglican Principal ChaplainThe Venerable Glenn Buijs (Archdeacon of the Army)InsigniaCap badgeCrowned Maltese cross (Christian chaplains), Crowned Star of David (Jewish chaplains)Lany...

 

List of shipwrecks of Cornwall (20th century)

The list of shipwrecks of Cornwall (20th century) lists the ships which sank on or near the coasts of mainland Cornwall in that period. The list includes ships that sustained a damaged hull, which were later refloated and repaired: For ships wrecked both before and after the 20th century see List of shipwrecks of Cornwall For ships wrecked off the Isles of Scilly see List of shipwrecks of the Isles of Scilly. For ships wrecked on the Seven Stones Reef see List of shipwrecks of the Seven Ston...

Presidential transition of Dwight D. Eisenhower

Presidential Transition of the 34th President of the United States Presidential transition of Dwight D. EisenhowerPresident-elect Eisenhower speaks with reporters while visiting the White House on November 18, 1952Date of electionNovember 4, 1952Inauguration dateJanuary 20, 1953President-electDwight D. Eisenhower (Republican)Vice president-electRichard Nixon (Republican)Outgoing presidentHarry S. Truman (Democrat)Outgoing vice presidentAlben W. Barkley (Democrat)HeadquartersCommodore Hotel, N...

 

The Ideal Scout

Sculpture by R. Tait McKenzie The original statue in Philadelphia The Ideal Scout, also known as The Boy Scout, is a work by Canadian[1] sculptor R. Tait McKenzie (1867–1938). The original statue stood in front of the Cradle of Liberty Council at 22nd and Winter Streets in Philadelphia, Pennsylvania, from 1937 to 2013.[2] Replicas can be found at Boy Scouts of America councils across the United States, as well as at Gilwell Park in London, England, and at Scouts Canada's nat...

 

Haji ifrad

Bagian dari seriIslam Rukun Iman Keesaan Allah Malaikat Kitab-kitab Allah Nabi dan Rasul Allah Hari Kiamat Qada dan Qadar Rukun Islam Syahadat Salat Zakat Puasa Haji Sumber hukum Islam al-Qur'an Sunnah (Hadis, Sirah) Tafsir Akidah Fikih Syariat Sejarah Garis waktu Muhammad Ahlulbait Sahabat Nabi Khulafaur Rasyidin Khalifah Imamah Ilmu pengetahuan Islam abad pertengahan Penyebaran Islam Penerus Muhammad Budaya dan masyarakat Akademik Akhlak Anak-anak Dakwah Demografi Ekonomi Feminisme Filsafat...

Ole Worm

Danish scientist (1588–1654) Ole WormBorn13 May 1588Aarhus, DenmarkDied31 August 1654(1654-08-31) (aged 66)Copenhagen, DenmarkNationalityDanishOther namesOlaus WormiusOccupation(s)physician, natural historian and antiquarySpouseDorothea FinckeFamilyChristen Worm (grandson) Ole Worm and Dorothea Worm, née Fincke Ole Worm (13 May 1588 – 31 August 1654), who often went by the Latinized form of his name Olaus Wormius, was a Danish physician, natural historian and antiquary. He was...

 

Spotify

Swedish audio streaming service Not to be confused with Shopify. Spotify Technology S.A.Type of businessPublic companyTraded asNYSE: SPOTRussell 1000 componentFounded23 April 2006; 18 years ago (2006-04-23)HeadquartersStockholm, Sweden[1][2]Country of originSwedenNo. of locations15 offices[2]Founder(s)Daniel EkMartin LorentzonKey peopleDaniel Ek (Chairman & CEO)Martin Lorentzon (treasurer)IndustryAudio streamingPodcastingRevenu...