Louise Rollins-Smith
Louise Rollins-Smith is a professor of biological sciences, professor of pediatrics, and a professor of pathology, microbiology and immunology at Vanderbilt University . She is known for her work investigating host-pathogen interactions using amphibians as model organisms.
Education and career
Rollins-Smith received her Bachelor's degree in Biology at Hamline University , Saint Paul, Minnesota, before completing a Masters and a Ph.D. in zoology at the University of Minnesota in 1977.[ 1] University of Rochester before joining Vanderbilt University in 1984.[ 2]
Research
Rollins-Smith has studied disease and immunity in amphibians . Her early research was focused upon Lucké renal adenocarcinoma of leopard frogs ,[ 3] [ 4] immunological tolerance and immune changes at metamorphosis in frogs.[ 5] [ 6] [ 7] amphibian declines and the amphibian chytrid fungi, Bactrochochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal),[ 8] [ 9] [ 10] antimicrobial peptides (AMPs). Alongside her colleagues, she has provided evidence that the effectiveness of AMPs is a valuable predictor of amphibian species susceptibility to the Bd,[ 11] [ 12]
Selected publications
Carey, Cynthia; Cohen, Nicholas; Rollins-Smith, Louise (1999-09-01). "Amphibian declines: an immunological perspective" . Developmental & Comparative Immunology . 23 (6): 459– 472. doi :10.1016/S0145-305X(99)00028-2 . ISSN 0145-305X . PMID 10512457 . Rollins-Smith, Louise A. (1998). "Metamorphosis and the amphibian immune system" . Immunological Reviews . 166 (1): 221– 230. doi :10.1111/j.1600-065X.1998.tb01265.x . ISSN 1600-065X . PMID 9914915 . Woodhams, D. C.; Ardipradja, K.; Alford, R. A.; Marantelli, G.; Reinert, L. K.; Rollins-Smith, L. A. (2007). "Resistance to chytridiomycosis varies among amphibian species and is correlated with skin peptide defenses" . Animal Conservation . 10 (4): 409– 417. Bibcode :2007AnCon..10..409W . doi :10.1111/j.1469-1795.2007.00130.x . ISSN 1367-9430 . Rollins-Smith, Louise A. (2009-08-01). "The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines" . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1788 (8): 1593– 1599. doi :10.1016/j.bbamem.2009.03.008 . ISSN 0005-2736 . PMID 19327341 . Ramsey, Jeremy P.; Reinert, Laura K.; Harper, Laura K.; Woodhams, Douglas C.; Rollins-Smith, Louise A. (2010). "Immune Defenses against Batrachochytrium dendrobatidis, a Fungus Linked to Global Amphibian Declines, in the South African Clawed Frog, Xenopus laevis" . Infection and Immunity . 78 (9): 3981– 3992. doi :10.1128/iai.00402-10 . PMC 2937463 PMID 20584973 .
References
^ "Vanderbilt University School of Medicine" . wag.app.vanderbilt.edu . Retrieved 2023-12-12 .^ "Rollins-Smith Lab Members | The Rollins-Smith Lab" . www.vumc.org . Retrieved 2023-12-12 .^ Rollins-Smith, Louise A.; Cohen, Nicholas (September 1984). "Effect of Thyroxine on Induction of Lucké Renal Adenocarcinomas in Lucké Tumor Herpesvirus-Infected Leopard Frog Tadpoles2" . JNCI: Journal of the National Cancer Institute . 73 (3): 717– 720. doi :10.1093/jnci/73.3.717 . ISSN 1460-2105 . PMID 6332231 . ^ Rollins-Smith, Louise A.; Cohen, Nicholas (January 1982). "Effect of Thymectomy on Development of Lucké Renal Adenocarcinomas in Virus-Infected Leopard Frog Tadpoles23" . JNCI: Journal of the National Cancer Institute . 68 (1): 133– 138. doi :10.1093/jnci/68.1.133 . ISSN 1460-2105 . ^ Rollins-Smith, Louise A.; Blair, Patrick J.; Davis, A. Tray (1992). "Thymus Ontogeny in Frogs: T-Cell Renewal at Metamorphosis" . Journal of Immunology Research . 2 (3): 207– 213. doi :10.1155/1992/26251 ISSN 2314-8861 . PMC 2275863 PMID 1320967 . ^ Rollins-Smith, Louise A.; Hopkins, B. Diane (1997-03-01). "F2 2:00 Immunotoxic effects of diazinon and lead on the developing hematopoietic system of Xenopus laevis" . Developmental & Comparative Immunology . The 7th Congress of The International Society of Developmental and Comparative Immunology. 21 (2): 121. doi :10.1016/S0145-305X(97)88572-2 . ISSN 0145-305X . ^ Christin, M. S.; Ménard, L.; Gendron, A. D.; Ruby, S.; Cyr, D.; Marcogliese, D. J.; Rollins-Smith, L.; Fournier, M. (2004-03-30). "Effects of agricultural pesticides on the immune system of Xenopus laevis and Rana pipiens" . Aquatic Toxicology . 67 (1): 33– 43. Bibcode :2004AqTox..67...33C . doi :10.1016/j.aquatox.2003.11.007 . ISSN 0166-445X . PMID 15019249 . ^ "Amphibian population on the decline" . Stewart-Houston Times . 1998-10-27. p. 15. Retrieved 2025-01-07 .^ Brown, Josh (2014-07-14). "Scientists find new weapon to fight deadly frog virus" . The Tennessean . pp. A13. Retrieved 2025-01-07 . ^ Phelan, Meagan (17 October 2013). "Fatal Frog Fungus Maneuvers Past Immune System" . American Association for the Advancement of Science (AAAS) . Retrieved 2025-01-07 . ^ Rollins-Smith, Louise A.; Doersam, Jennifer K.; Longcore, Joyce E.; Taylor, Sharon K.; Shamblin, Jessica C.; Carey, Cynthia; Zasloff, Michael A. (2002-01-01). "Antimicrobial peptide defenses against pathogens associated with global amphibian declines" . Developmental & Comparative Immunology . 26 (1): 63– 72. doi :10.1016/S0145-305X(01)00041-6 . ISSN 0145-305X . PMID 11687264 . ^ Pinto, Claudia (2005-10-21). "Frog secretions block HIV infections, VU study finds" . The Tennessean . pp. A1, [1] . Retrieved 2025-01-07 .
External links
