Lottie Williams may refer to:

• Lottie Williams (actress, born 1866) (1866–1929), American actress
• Lottie Williams (actress, born 1874) (1874–1962), American actress
• Lottie Williams, an Oklahoma resident who is the only person to have been struck by re-entering space debris, when a small piece of the rocket launching the Midcourse Space Experiment harmlessly struck her shoulder in 1997
• Lottie Williams, a victim of a 1980 murder for which Leonard Marvin Laws was executed by the U.S. state of Missouri in 1990

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