On 28 October 1909, route 22 was changed again to work between Tulse Hill and Leyton via Effra Road, Brixton Road, Kennington Park Road, Elephant & Castle and Whipps Cross. On 3 January 1910, it was cut back again to work Clapton (Lea Bridge station) to Tulse Hill.[1]
From 6 April 1911, route 22 was withdrawn between Bank and Elephant & Castle, being replaced by new route 35 over that section. At the same time it was extended to Putney station via Cheapside, Holborn, Piccadilly, King's Road and Putney Bridge. The daily extension to Homerton (Clapton Park Tavern) commenced soon after on 12 June 1911, but the route was withdrawn throughout on Sundays on 8 October 1911 for just over three years until 8 November 1914, when it became daily once again.[1]
The connection with route 35 became clear once again as from 6 August 1916, when route 22 was diverted daily at Putney Bridge to run to Putney Common, but withdrawn on Sundays between Lower Clapton and Homerton being extended to Chingford via Leyton and Walthamstow, replacing route 35A on that day. This change was very short lived and route 22 reverted to being a daily Putney Common to Homerton route on 2 October 1916.[1]
On 1 December 1924, short-workings between Tottenham Court Road and Putney were numbered 22A, short-workings between Tottenham Court Road and Homerton were numbered 22B and short-workings between Piccadilly Circus and Homerton were numbered 22C. The plain 22 route number being used for journeys for the whole length of the route from Putney Common to Homerton. By 30 June 1925, these had been reduced to 22 Putney Common to Homerton and 22A Piccadilly Circus - Homerton. This situation remained until 3 October 1934, when the newly constituted London Passenger Transport Board instituted its own numbering system, which generally re-instated the situation previous to December 1924, in this case, leaving just the plain 22 to work Putney Common to Homerton.[1]
On 9 August 1939, RT1 buses were used to run the route from Homerton to Putney.[2]
By the 1990s, the three short workings had become 3 distinct routes, with route 22 from Putney Common to Piccadilly Circus, route 22A running from London Bridge to Clapton Park and route 22B from Homerton Hospital to Piccadilly Circus. Owing to the confusion, the 22A and 22B routes were withdrawn in 1998, and replaced by a new route 242 and an extension of route 149.[citation needed]