Livedo reticularis

Livedo reticularis
Livedo reticularis secondary to obscure severe infrarenal aortoiliac stenosis with severe transient lactic acidosis.
SpecialtyDermatology, cardiology Edit this on Wikidata
SymptomsPurpura, mottling of the skin, blood clots, skin discoloration
CausesAutoimmune diseases, hyperlipidemia, poisons, drug abuse

Livedo reticularis is a common skin finding consisting of a mottled reticulated vascular pattern that appears as a lace-like purplish discoloration of the skin.[1] The discoloration is caused by reduction in blood flow (ischemia) through the arterioles that supply the cutaneous capillaries, resulting in deoxygenated blood showing as blue discoloration (cyanosis). This can be a secondary effect of a condition that increases a person's risk of forming blood clots (thrombosis), including a wide array of pathological and nonpathological conditions. Examples include hyperlipidemia, microvascular hematological or anemia states, nutritional deficiencies, hyper- and autoimmune diseases, and drugs/toxins.

The condition may be normal or related to more severe underlying pathology.[2] Its differential diagnosis is broadly divided into possible blood diseases, autoimmune (rheumatologic), cardiovascular diseases, cancers, and endocrine disorders. It can usually (in 80% of cases) be diagnosed by biopsy.[3]

It may be aggravated by exposure to cold, and occurs most often in the lower extremities.[4]

The condition's name derives from Latin livere 'bluish' and reticular 'net-like pattern'.[5]

Causes

A number of conditions may cause the appearance of livedo reticularis:

Diagnosis

Livedo reticularis is diagnosed by its clinical appearance and history. No further test or examination confirms idiopathic livedo reticularis. However, further investigations may be undertaken where an underlying cause is suspected such as skin biopsies, or blood tests for antibodies associated with antiphospholipid syndrome or systemic lupus erythematosus.[46]

Treatment

Other than identifying and treating any underlying conditions in secondary livedo,[47] idiopathic livedo reticularis may improve with warming the area.

See also

References

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1615. ISBN 978-1-4160-2999-1.
  2. ^ "livedo reticularis" at Dorland's Medical Dictionary
  3. ^ Kroshinsky; Stone, John H.; Bloch, Donald B.; Sepehr, Alireza (February 2009). "Case 5-2009 — A 47-Year-Old Woman with a Rash and Numbness and Pain in the Legs". New England Journal of Medicine. 360 (7): 711–20. doi:10.1056/NEJMcpc0807822. PMID 19213685.
  4. ^ James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "35.Cutaneous vascular diseases". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 817. ISBN 978-0-323-54753-6. Archived from the original on 2023-03-18. Retrieved 2023-03-18.
  5. ^ Sundriyal, Deepak; Kumar, Naveen; Kumar, Gaurav; Walia, Meenu (15 May 2014). "Livedo reticularis heralding hypercalcaemia of malignancy". BMJ Case Reports. 2014 (may14 4): bcr2013201371. doi:10.1136/bcr-2013-201371. PMC 4024535. PMID 24832704.
  6. ^ Sneddon IB (April 1965). "Cerebro-Vascular Lesions And Livedo Reticularis". British Journal of Dermatology. 77 (4): 180–5. doi:10.1111/j.1365-2133.1965.tb14628.x. PMID 14278790. S2CID 43219068.
  7. ^ Gibbs, Mark B.; English, Joseph C.; Zirwas, Matthew J. (2005). "Livedo reticularis: an update". J Am Acad Dermatol. 52 (6): 1009–19. doi:10.1016/j.jaad.2004.11.051. PMID 15928620.
  8. ^ Feldaker M, Hines E, Kierland R (1955). "Livedo reticularis with summer ulcerations". AMA Arch Dermatol. 72 (1): 31–42. doi:10.1001/archderm.1955.03730310033007. PMID 14387292.
  9. ^ Golden R (March 1963). "Livedo reticularis in systemic lupus erythematosus". Arch Dermatol. 87 (3): 299–301. doi:10.1001/archderm.1963.01590150015002. PMID 13948706.
  10. ^ Sigmund W, Shelley W (1954). "Cutaneous manifestations of acute pancreatitis, with special reference to livedo reticularis". N Engl J Med. 251 (21): 851–3. doi:10.1056/NEJM195411182512104. PMID 13214346.
  11. ^ Gould, Jennifer W.; Helms, Stephen E.; Schulz, Susan M.; Stevens, Seth R. (1998). "Relapsing livedo reticularis in the setting of chronic pancreatitis". Journal of the American Academy of Dermatology. 39 (6): 1035–1036. doi:10.1016/S0190-9622(98)70290-7. PMID 9843029.
  12. ^ Rot, Uroš; Ledinek, Alenka Horvat (December 2013). "Interferons beta have vasoconstrictive and procoagulant effects: a woman who developed livedo reticularis and Raynaud phenomenon in association with interferon beta treatment for multiple sclerosis". Clinical Neurology and Neurosurgery. 115 (Suppl 1): S79–81. doi:10.1016/j.clineuro.2013.09.027. PMID 24321162. S2CID 11757438.
  13. ^ Fox, Michelle; Tahan, Steven; Kim, Caroline C. (2012). "Livedo Reticularis: A Side Effect of Interferon Therapy in a Pediatric Patient with Melanoma". Pediatric Dermatology. 29 (3): 333–5. doi:10.1111/j.1525-1470.2011.01426.x. PMID 21575046. S2CID 37285113.
  14. ^ Cruz, Boris Afonso; de Queiroz, Eustáquio; Nunes, Simone Vilela; Cruz Filho, Achiles; Campos, Gilberto Belisario; de Carvalho Monteiro, Ernesto Lentz; Crivellari, Humberto (2000). "Fênomeno de Raynaud grave associado a terapia com interferon-beta para esclerose múltipla: relato de caso" [Severe Raynaud's phenomenon associated with interferon-beta therapy for multiple sclerosis: case report]. Arquivos de Neuro-Psiquiatria (in Portuguese). 58 (2B): 556–9. doi:10.1590/S0004-282X2000000300025. PMID 10920422.
  15. ^ Strowd, Lindsay C.; Lee, Andrew D.; Yosipovitch, Gil (June 2012). "Livedo Reticularis Associated With Rasagiline (Azilect)". Journal of Drugs in Dermatology. 11 (6): 764–5. PMID 22648227. Archived from the original on 2021-03-05. Retrieved 2014-03-21.
  16. ^ Syed, Reema H.; Moore, Terry L. (2008). "Methylphenidate and Dextroamphetamine-Induced Peripheral Vasculopathy". Journal of Clinical Rheumatology. 14 (1): 30–33. doi:10.1097/RHU.0b013e3181639aaa. PMID 18431096.
  17. ^ Blume, Jonathan E.; Miller, Craig C. (2007). "Livedo reticularis with retiform purpura associated with gefitinib (Iressa®)". International Journal of Dermatology. 46 (12): 1307–8. doi:10.1111/j.1365-4632.2007.03319.x. PMID 18173531. S2CID 43388374.
  18. ^ Langhof H, Braun G, Matzkowski H (1957). "Livedo reticularis durch Kältegelierung des Blutes bei γ-Plasmocytom" [Livedo reticularis due to cold gelation of the blood by gamma-plasmacytoma]. Archiv für Klinische und Experimentelle Dermatologie (in German). 205 (4): 343–50. doi:10.1007/BF00693523. PMID 13522017. S2CID 10434333.
  19. ^ Kazmier F, Sheps S, Bernatz P, Sayre G (1966). "Livedo reticularis and digital infarcts: a syndrome due to cholesterol emboli arising from atheromatous abdominal aortic aneurysms". Vasc Dis. 3 (1): 12–24. PMID 5903590.
  20. ^ Stewart W, Lauret P, Testart J, Thomine E, Boulliê M, Leroy D (1977). "Les manifestations cutanées des emoblies de critaux de cholestérol" [Cutaneous cholesterol emboli]. Ann Dermatol Venereol (in French). 104 (1): 5–8. PMID 843026.
  21. ^ Buckley, Sarah A.; Lessing, Juan N.; Mark, Nicholas M. (2013). "Livedo Reticularis in a Patient with Pheochromocytoma Resolving After Adrenalectomy". The Journal of Clinical Endocrinology & Metabolism. 98 (2): 439–40. doi:10.1210/jc.2012-2842. PMID 23275529.
  22. ^ Yong AA, Tan AW, Giam YC, Tang MB (December 2012). "Livedoid vasculopathy and its association with factor V Leiden mutation" (PDF). Singapore Med J. 53 (12): e258–60. PMID 23268168. Archived (PDF) from the original on 2016-03-04. Retrieved 2014-03-22.
  23. ^ Pachlopnik Schmid, Jana; Lemoine; Nehme, Nadine; Cormier-Daire, Valéry; Revy, Patrick; Debeurme, Franck; Debré, Marianne; Nitschke, Patrick; Bole-Feysot, Christine; Legeai-Mallet, Laurence; Lim, Annick; de Villartay, Jean-Pierre; Picard, Capucine; Durandy, Anne; Fischer, Alain; de Saint Basile, Geneviève (2012). "Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature ('FILS syndrome')" (PDF). Journal of Experimental Medicine. 209 (13): 2323–30. doi:10.1084/jem.20121303. PMC 3526359. PMID 23230001.
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  25. ^ Bogle MA, Teller CF, Tschen JA, Smith CA, Wang A (October 2003). "Primary hyperoxaluria in a 27-year-old woman". J. Am. Acad. Dermatol. 49 (4): 725–8. doi:10.1067/s0190-9622(03)00119-1. PMID 14512927.
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  28. ^ Singh S, Tai C, Ganz G, et al. (April 1999). "Steroid-responsive pleuropericarditis and livedo reticularis in an unusual case of adult-onset primary hyperoxaluria". Am. J. Kidney Dis. 33 (4): e5.1–e5.6. doi:10.1016/s0272-6386(99)70246-5. PMID 10196036.
  29. ^ Arslan, Ferhat; Batirel, Ayse; Mert, Ali; Ozer, Serdar (2012). "Cytomegalovirus (CMV)-related cutaneous necrotizing vasculitis: Case report and literature review". The Brazilian Journal of Infectious Diseases. 16 (5): 482–5. doi:10.1016/j.bjid.2012.08.002. PMID 22975173.
  30. ^ Camacho, Diana; Machan, Shalma; Pilesanski, Ursula; Revelles, Juan Maria; Martín, Lucia; Requena, Luis (2012). "Generalized Livedo Reticularis Induced by Silicone Implants for Soft Tissue Augmentation". The American Journal of Dermatopathology. 34 (2): 203–7. doi:10.1097/DAD.0b013e31821cb3c5. PMID 22441370.
  31. ^ Bilgili SG, Akdeniz N, Karadag AS, Akbayram S, Calka O, Ozkol HU (2011). "Mucocutaneous disorders in children with down syndrome: case-controlled study". Genet. Couns. 22 (4): 385–92. PMID 22303799.
  32. ^ Daneshpazhooh M, Nazemi TM, Bigdeloo L, Yoosefi M (2007). "Mucocutaneous findings in 100 children with Down syndrome". Pediatr Dermatol. 24 (3): 317–20. doi:10.1111/j.1525-1470.2007.00412.x. PMID 17542890. S2CID 25151006.
  33. ^ ENDO, Yuichiro; MIYACHI, Yoshiki; YOSHIKAWA, Yoshiaki (2011). "John Libbey Eurotext : Éditions médicales et scientifiques France : revues, médicales, scientifiques, médecine, santé, livres". European Journal of Dermatology. 21 (2). Jle.com: 266–7. doi:10.1684/ejd.2010.1226. PMID 21489905.
  34. ^ Johnson, Philip L.; Neperud, Julie; Arnold, Jill; Thomas, James (2011). "Livedo Reticularis and Bowel Ischemia after Carbon Dioxide Arteriography in a Patient with CREST Syndrome". Journal of Vascular and Interventional Radiology. 22 (3): 395–9. doi:10.1016/j.jvir.2010.11.012. PMID 21277800.
  35. ^ Marzano, AV; Balice, Y; Tavecchio, S; Desimine, C; Colombo, A; Berti, E (April 2015). "Granulomatous vasculitis". Giornale Italiano di Dermatologia e Venereologia. 150 (2): 193–202. PMID 25791629.
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  37. ^ a b Tabata, N; Oonami, K; Ishibashi, M; Yamazaki, M (2010). "Livedo Vasculopathy Associated with IgM Anti-phosphatidylserine-prothrombin Complex Antibody". Acta Dermato Venereologica. 90 (3): 313–4. doi:10.2340/00015555-0835. PMID 20526560.
  38. ^ Gambichler, T.; Baier, P.; Altmeyer, P. (2009). "Generalized livedo reticularis as the first sign of metastatic breast carcinoma". Clinical and Experimental Dermatology. 34 (2): 253–4. doi:10.1111/j.1365-2230.2008.02801.x. PMID 19120398. S2CID 1965405.
  39. ^ Erel, Arzu; Ozsoy, Esra; University, Gazi (2001). "Livedo reticularis associated with renal cell carcinoma". International Journal of Dermatology. 40 (4): 299–300. doi:10.1046/j.1365-4362.2001.00895.x. PMID 11454094. S2CID 46560722.
  40. ^ Takanashi, Tetsuo; Horigome, Reiko; Okuda, Yasuaki; Nose, Masato; Matsuda, Masayuki; Ikeda, Shu-Ichi (2007). "Buerger's Disease Manifesting Nodular Erythema with Livedo Reticularis". Internal Medicine. 46 (21): 1815–9. doi:10.2169/internalmedicine.46.0143. PMID 17978541.
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