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This is a list of people who were born in, have been residents of, or are otherwise associated with the city of Fayetteville, Arkansas.

• Lisa Blount, actress and Oscar-winning producer
• Brent Bradshaw, writer and performer
• TJ Holmes, CNN anchor
• Jason Moore, director of 2004 Tony Award Best Musical Avenue Q
• Maddy Morphosis, drag queen contestant of the fourteenth season of RuPaul's Drag Race
• Mary Kate Wiles, actress and producer

• Ronnie Brewer, former Arkansas Razorback and NBA player
• Blake Parker, former Arkansas Razorback and MLB pitcher
• Wallace Spearmon, former Arkansas Razorback and Olympic sprinter
• Payton Willis (born 1998), basketball player in the Israeli Basketball Premier League

• Fleda Brown, poet and author
• Richard Corben, comic book artist for Heavy Metal
• Ellen Gilchrist, novelist
• Donald Harington, author
• E. Lynn Harris, author of ten consecutive The New York Times Best Seller list books
• Joan Hess, author of the Claire Malloy and Arly Hanks mystery series
• George Johnson, science writer and author
• Douglas C. Jones, historical fiction author
• John Rollin Ridge, first Native American novelist
• John Edward Williams, novelist and poet
• Miller Williams, poet

• Cate Brothers, singer-songwriter musician duo
• Ronnie Hawkins, rockabilly musician
• Nick Shoulders, country musician
• Lucinda Williams, Grammy Award-winning songwriter and daughter of Miller Williams

• Jim Bryson, member of the Tennessee Senate from District 23
• Bill Clinton, 42nd U.S. President and former Arkansas governor
• Hillary Clinton, former U.S. Secretary of State, First Lady, and U.S. Senator
• Lance Eads, Republican member of the Arkansas House of Representatives for Washington County since 2015; former resident
• J. William Fulbright, former U.S. Senator
• John W. Grabiel, Republican gubernatorial nominee in 1922 and 1924; Ohio native, attorney in Fayetteville until his death in 1928
• Lafayette Gregg, Associate Justice of the Arkansas Supreme Court 1868–1874, Republican member of the Arkansas House of Representatives for Washington County 1854–1856
• Grant Hodges, Republican member of the Arkansas House of Representatives for Benton County since 2015; former Fayetteville resident
• Jim House, Democratic member of the Arkansas House of Representatives
• Ben Hulse, member of the California State Senate, born and reared near Fayetteville
• Dustin McDaniel, former Attorney General of Arkansas
• David Pryor, former Arkansas governor and former U.S. senator
• Mark Pryor, former U.S. Senator