Since Uruguay's first official international football match in 1902, there have been 33 occasions when a Uruguayan player has scored three or more goals (a hat-trick) in a game. The first hat-trick was scored by José Piendibene against Argentina in 1919. The record for most goals scored in an international match by a Uruguayan player is five, which has been achieved by Héctor Scarone against Bolivia in 1926.

With three hat-tricks, Pedro Petrone and Javier Ambrois shares the record for most international hat-tricks scored by a Uruguayan player. Petrone is also the only Uruguayan to score a hat-trick in Olympics. Pedro Cea (1930), Óscar Míguez (1950) and Carlos Borges (1954) are the only three Uruguayan players to score a hat-trick in a FIFA World Cup match. Last player to score a hat-trick for Uruguay is Darwin Núñez, who found the net three times in a friendly match against Mexico.^[1]

Uruguay have conceded 21 hat-tricks in their history, 10 of them in matches against Argentina. Last player to score a hat-trick against Uruguay is Brazilian midfielder Paulinho.^[2]

Note: Whenever scores and results are mentioned in this article, Uruguay's goal tally is given first.

Date	Player	Goals	Opponent	Venue	Result	Competition	Ref(s)
7 December 1919	José Piendibene	3	Argentina	Parque Pereira, Montevideo	4–2	Friendly	[3]
2 November 1921	Felipe Buffoni [de]	3	Paraguay	Estadio Gran Parque Central, Montevideo	4–2	Friendly	[4]
19 October 1924	Pedro Petrone	3	Chile	Estadio Gran Parque Central, Montevideo	5–0	1924 South American Championship	[5]
28 October 1926	Héctor Scarone	5	Bolivia	Estadio Campos de Sports de Ñuñoa, Santiago	6–0	1926 South American Championship	[6]
1 November 1926	Héctor Castro	4	Paraguay	Estadio Campos de Sports de Ñuñoa, Santiago	6–1	1926 South American Championship	[7]
6 November 1927	Roberto Figueroa	3	Bolivia	Estadio Nacional, Lima	9–0	1927 South American Championship	[8]
6 November 1927	Pedro Petrone	3	Bolivia	Estadio Nacional, Lima	9–0	1927 South American Championship	[8]
3 June 1928	Pedro Petrone	3	Germany	Olympic Stadium, Amsterdam	4–1	1928 Summer Olympics	[9]
11 November 1929	Lorenzo Fernández	3	Peru	Estadio Alvear y Tagle, Buenos Aires	4–1	1929 South American Championship	[10]
27 July 1930	Pedro Cea	3	Yugoslavia	Estadio Centenario, Montevideo	6–1	1930 FIFA World Cup	[11]
22 January 1939	Severino Varela	3	Ecuador	Estadio Nacional, Lima	6–0	1939 South American Championship	[12]
9 February 1941	Ismael Rivero [es]	3	Ecuador	Estadio Nacional, Santiago	6–0	1941 South American Championship	[13]
18 January 1942	Severino Varela	3	Ecuador	Estadio Centenario, Montevideo	7–0	1942 South American Championship	[14]
24 January 1945	Atilio García	3	Ecuador	Estadio Nacional, Santiago	5–1	1945 South American Championship	[15]
29 January 1946	José María Medina	4	Bolivia	Estadio de Independiente, Avellaneda	5–0	1946 South American Championship	[16]
2 July 1950	Óscar Míguez	3	Bolivia	Estádio Independência, Belo Horizonte	8–0	1950 FIFA World Cup	[17]
30 March 1952	Óscar Míguez	3	Peru	Estadio Nacional, Santiago	5–2	Friendly	[18]
6 April 1952	Julio Abbadie	3	Panama	Estadio Nacional, Santiago	6–1	Friendly	[19]
5 June 1954	Javier Ambrois	3	Saarland	Ludwigsparkstadion, Saarbrücken	7–1	Friendly	[20]
19 June 1954	Carlos Borges	3	Scotland	St. Jakob Stadium, Basel	7–0	1954 FIFA World Cup	[21]
7 March 1957	Javier Ambrois	4	Ecuador	Estadio Nacional, Lima	5–2	1957 South American Championship	[22]
23 March 1957	Javier Ambrois	4	Peru	Estadio Nacional, Lima	5–3	1957 South American Championship	[23]
23 May 1965	Héctor Silva	3	Venezuela	Estadio Centenario, Montevideo	5–0	1966 FIFA World Cup qualification	[24]
18 December 1980	Rubén Paz	3	Switzerland	Estadio Luis Tróccoli, Montevideo	4–0	Friendly	[25]
10 February 1985	Amaro Nadal	3	Paraguay	Estadio Defensores del Chaco, Asunción	3–1	Friendly	[26]
15 August 2003	Martín Ligüera	3	Iraq	Azadi Stadium, Tehran	5–2	Friendly	[27]
4 September 2005	Marcelo Zalayeta	3	Colombia	Estadio Centenario, Montevideo	3–2	2006 FIFA World Cup qualification	[28]
17 June 2008	Diego Forlán	3	Peru	Estadio Centenario, Montevideo	6–0	2010 FIFA World Cup qualification	[29]
8 October 2010	Luis Suárez	3	Indonesia	Gelora Bung Karno Stadium, Jakarta	7–1	Friendly	[30]
8 October 2010	Edinson Cavani	3	Indonesia	Gelora Bung Karno Stadium, Jakarta	7–1	Friendly	[30]
11 November 2011	Luis Suárez	4	Chile	Estadio Centenario, Montevideo	4–0	2014 FIFA World Cup qualification	[31]
23 June 2013	Abel Hernández	4	Tahiti	Arena Pernambuco, Recife	8–0	2013 FIFA Confederations Cup	[32]
5 June 2024	Darwin Núñez	3	Mexico	Empower Field at Mile High, Denver	4–0	Friendly	[33]

Date	Player	Goals	Opponent	Venue	Result	Competition	Ref(s)
13 July 1913	Carlos Guidi	3	Argentina	Estadio Gran Parque Central, Montevideo	5–4	Friendly	[34]
15 August 1913	Maximiliano Susán	4	Argentina	Estadio Racing Club, Avellaneda	0–4	Friendly	[35]
1 October 1916	Marius Hiller	3	Argentina	Estadio Racing Club, Avellaneda	2–7	Friendly	[36]
19 October 1919	Julio Libonatti	3	Argentina	Estadio G.E.B.A., Buenos Aires	1–6	Friendly	[37]
5 February 1933	Roberto Cherro	4	Argentina	Estadio de Independiente, Avellaneda	1–4	Friendly	[38]
11 November 1937	Herminio Masantonio	3	Argentina	Estadio de Independiente, Avellaneda	1–5	Friendly	[39]
29 January 1944	René Pontoni	3	Argentina	Estadio Gasómetro, Buenos Aires	2–6	Friendly	[40]
18 May 1944	Jair da Rosa Pinto	3	Brazil	Pacaembu Stadium, São Paulo	0–4	Friendly	[41]
1 March 1953	Francisco Molina	3	Chile	Estadio Nacional, Lima	2–3	1953 South American Championship	[42]
27 March 1955	Ángel Labruna	3	Argentina	Estadio Nacional, Santiago	1–6	1955 South American Championship	[43]
14 July 1957	Florencio Amarilla	3	Paraguay	Estadio Defensores del Chaco, Asunción	0–5	FIFA World Cup qualifiers	[44]
14 March 1959	Miguel Ángel Loayza	3	Peru	El Monumental, Buenos Aires	3–5	1959 South American Championship (Argentina)	[45]
26 March 1959	Paulo Valentim	3	Brazil	El Monumental, Buenos Aires	1–3	1959 South American Championship (Argentina)	[46]
17 August 1960	José Sanfilippo	3	Argentina	El Monumental, Buenos Aires	0–4	Friendly	[47]
27 April 1962	Aleksei Mamykin	3	Soviet Union	Central Lenin Stadium, Moscow	0–5	Friendly	[48]
26 June 1966	José Torres	3	Portugal	Estádio Nacional, Oeiras	0–3	Friendly	[49]
8 June 1986	Preben Elkjær	3	Denmark	Estadio Neza 86, Nezahualcóyotl	1–6	1986 FIFA World Cup	[50]
16 November 1997	Ariel Graziani	3	Ecuador	Estadio Domingo Burgueño, Maldonado	5–3	1998 FIFA World Cup qualification	[51]
10 September 2003	José Cardozo	3	Paraguay	Estadio Defensores del Chaco, Asunción	1–4	2006 FIFA World Cup qualification	[52]
16 October 2012	Carlos Saucedo	3	Bolivia	Estadio Hernando Siles, La Paz	1–4	2014 FIFA World Cup qualification	[53]
23 March 2017	Paulinho	3	Brazil	Estadio Centenario, Montevideo	1–4	2018 FIFA World Cup qualification	[54]