This is a list of notable footballers who have played for Iraklis F.C.. Generally, this means players that have played 100 or more first-class matches for the club. A number of other players who have played an important role in a title win can also be included for their contribution. Club captains and seasonal top goalscorers are included. Players in Iraklis' early history are also included despite not necessarily playing 100 matches.

For a list of all Iraklis players, major or minor, with a Wikipedia article, see Category:Iraklis F.C. (Thessaloniki) players, and for the current squad see the main Iraklis Thessaloniki F.C. article.

Players are listed according to the date of their first team debut. Appearances and goals are for first-team competitive matches only. Substitute appearances included.

Appearance figures as of 8 February 2020

Name	Nationality	Position	Iraklis career	Appearances	Goals	Notes
Alberto Nahmias		FW	?–?	?	?	Scored Greece's first goal ever.
Kostas Karapatis		GK	1946–1951, 1957–1961	?	0
Lolos Hasekidis		FW	1955–1962, 1966–1967	?	?
Zacharias Chaliabalias		MF	1963–1975	280	?
Kostas Aidiniou		MF	1964–1974, 1978–1979	232	57	1970-71, 1971-72, 1972-73 club's top goalscorer
Telis Batakis		MF	1966–1975	261	?
Makis Sentelidis		DF	1966–1978	312	6
Takis Nikoloudis		MF	1968–1976	233	?
Grigoris Fanaras		GK	1968–1982	244	?
Grigoris Zafiridis		DF	1969–1976	214	?
Vangelis Kousoulakis		MF	1971–1979	203	7
Dimitris Gesios		FW	1972–1980	211	75	All-time leader in league goals, 1973-74, 1975-76, 1976-77, 1977-78 club's top goalscorer
Babis Xanthopoulos		FW	1974–1987	283	14
Vasilis Hatzipanagis		MF	1975–1991	281	61	Greece's Golden Player
Lakis Papaioannou		MF	1979–1986	179	36	1985-86 club's top goalscorer
Savvas Kofidis		MF	1981–1988, 1997–1999	275	21
Daniil Papadopoulos		DF/MF/FW	1981–1998	419	64	All-time leader in league appearances
Sigurður Grétarsson		FW	1984–1985	26	10	Scored in the final of the 1985 Balkans Cup win, 1984-85 club's top goalscorer
Tasos Lefkopoulos		DF	1984–1991	140	1
Pagonis Vakalopoulos		DF	1984–1995	163	8
Giorgos Papadopoulos		DF/MF	1985–1997	225	18
Sakis Anastasiadis		MF	1986–1993	171	28	1986-87, 1987-88 club's top goalscorer
Fanis Toutziaris		FW	1987–1995	238	62	1993-94 club's top goalscorer
Thanasis Dimopoulos		FW	1988–1992	134	50	1988-89, 1989-90 and 1991-92 club's top goalscorer
Georgios Plitsis		GK	1988–1996	156	0
Christos Kostis		FW	1989–1994	110	24	1992-93 club's top goalscorer
Ivan Jovanović		MF	1989–1999	271	52	1996-97 club's top goalscorer
Predrag Erak		DF	1991–1995	100	4
Georgios Anatolakis		DF	1992–1996	134	4
Nikos Sakellaridis		DF	1992–1996	111	10
Giorgos Kostis		MF	1992–1999	171	9
Ieroklis Stoltidis		MF	1992–2003	234	33
Sotiris Konstantinidis		MF	1994–1999	110	14
Georgios Xenidis		DF	1995–2001, 2002–2004	195	18
Marios Christodoulou		FW	1995–1999	102	10
Nikos Mirtsekis		FW	1995–1997	62	31	1994-95 and 1995-96 club's top goalscorer
Georgios Kyriazis		DF	1996–2003, 2010–2011	188	9
Lazaros Semos		DF	1997–2000	107	9
Michalis Konstantinou		FW	1997–2001, 2008	165	84	1997-98, 1998-99, 1999-00 and 2000-01 club's top goalscorer
Ebenezer Hagan		MF	1998–2003	179	18
Ederson Fofonka		FW	2000–2004	124	43	2001-02 club's top goalscorer
Konstantinos Nebegleras		MF	2000–2004	128	5
Panagiotis Drougas		DF	2000–2007	146	1
Georgios Abaris		GK	2001–2007	114	0
Grigoris Papazacharias		DF	2001–2010	126	3
Anastasios Katsabis		DF	2002–2011	249	11	Club's captain 2006-2011
Mirosław Sznaucner		DF	2003–2007	109	0
Ilias Poursanidis		MF	2003–2008	143	2
Joël Epalle		MF	2005–2007, 2011	69	21	Club's captain 2005-2006, 2005-06 club's top goalscorer
Manolis Papasterianos		MF	2006–2011	104	5
Victoraș Iacob		FW	2009–2011	41	13	2009-10 club's top goalscorer
Paschalis Voutsias		MF	2009–2011, 2012–2014	30	2	Scored the 2,000th goal of Iraklis in top-tier league
Huanderson		GK	2012–2017	150	0
Emanuel Perrone		FW	2014–2017, 2018–2019	106	37
Taianan		MF	2013–2014, 2018–2020	57	16
Petros Kanakoudis		DF	2010–2011, 2018–2021	41	9

R.S.S.S.F.