Leopold Wilhelm von Baden married firstly in 1659 with Anna Silvia Caretto, Countess of Millesimo (1607 – February 26, 1664). They had no children.
Secondly he married on February 23, 1666 with Countess Maria Franziska of Fürstenberg-Heiligenberg (May 18, 1633 – March 7, 1702), daughter of Ernst Egon VIII, Count of Fürstenberg-Heiligenberg.
They had 6 children:
Leopold Wilhelm (January 20, 1667 – April 11, 1716), no issue
A son (January 20, 1667 – January 20, 1677)
Karl Friedrich Ferdinand (September 14, 1668 – September 14, 1680)