Leonard Henderson (October 6, 1772 – August 13, 1833) was an American jurist who served as chief justice of the North Carolina Supreme Court from 1829 to 1833, and an associate judge of that court beforehand.
Henderson served as a state superior court judge from 1808 until 1816. When the North Carolina General Assembly created the state Supreme Court in 1818, it elected Henderson as one of the first members of the three-judge court. The judges of the Court elected Henderson their Chief in 1829 after the death of Chief Justice Taylor. Henderson was also a trustee of the University of North Carolina at Chapel Hill.