Left-right determination factor 2
Left-right determination factor 2 (Lefty2) aka TGFB4 is a protein that is encoded by the LEFTY2 gene in humans.[5]
Function
Lefty2 is a protein from the TGF-beta cytokine family of proteins and is sometimes referred to as TGFB-4.[6][7] It is secreted and plays a role in left-right asymmetry determination of organ systems during development. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs.
Lefty2 is also sometimes referred to as Endometrial Bleeding-Associated Factor (EBAF).[6] Some types of infertility have been associated with dysregulated expression of this gene in the endometrium and the protein may play a role in endometrial bleeding.
Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000143768 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066652 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19.
- ^ a b GeneCards Human Gene Database. "LEFTY2 Gene - GeneCards | LFTY2 Protein | LFTY2 Antibody". www.genecards.org. Archived from the original on 2021-12-15. Retrieved 2025-04-03.
- ^ "LEFTY2 left-right determination factor 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-04-03.
Further reading
- Tabibzadeh S, Kothapalli R, Buyuksal I (1997). "Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily". Front. Biosci. 2: a18–25. doi:10.2741/a158. PMID 9230066.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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