In 2011 she joined University of California, Berkeley as a postdoctoral researcher working on Caribbean scorpions.[1][5] She studied the biogeography of arachnids.[6] She joined the California Academy of Sciences in 2015, and is one of the world's only women scorpion experts.[7][8][9] She continued to study Buthidae scorpions at the California Academy of Sciences.[10][11] She digitises and collects genetic information from the collected scorpion species.[7] She is also working on arthropods in salt flats in western America.[12] Her current research considers the evolution of scorpion venom and distribution of scorpions in the Caribbean.[8] She has also studied the uses of scorpion venom in the context of cancer research and medication.[13] In 2017 she discovered three new species and two new genera of club-tailed scorpions,[14][15][16][17] detecting the scorpions using ultraviolet lights that excite a fluorescent dye in the scorpion armour.[3][18] The new species were of the genus Rhopalurus.[16] Whilst surveying the Penang Hill rainforest in Malaysia, Esposito identified a new ghost scorpion.[19][20] In 2018 she identified that Centruroidinae scorpions hiss by rubbing themselves with comb like structures.[21][22] She told Slate magazine that her favourite fact about scorpions was that they behave like mammals and bear live young.[23][24]
In 2014, Esposito co-founded of Islands & Seas, a non-profit that supports scientific research and education at its field station in Baja California Sur, Mexico.[10][25][26][27] She leads educational programs in Baja California and at Columbia University.[28] She is the creator of 500 Queer Scientists, a network of LGBTQ+ scientists worldwide.[29][30][31][32][33] She created 500 Queer Scientists after a survey of American STEM workers identified that over 40% of LGBTQ+ scientists were not 'out' to their colleagues.[34][35] She has appeared on Science Friday and Public Radio International.[36][37] In February 2019 she was awarded the Walt Westman Award by the National Organization of Gay and Lesbian Scientists and Technical Professionals (NOGLSTP) as recognition for the 500 Queer Scientists initiative.[38] It is the highest national honor that NOGLSTP can award to a member, recognizing that individual's commitment to their mission.[39]
^ abA., Esposito, Lauren; Y., Yamaguti, Humberto; A., Souza, Cláudio; Ricardo., Pinto-da-Rocha; Lorenzo., Prendini (2017-06-26). "Systematic revision of the neotropical club-tailed scorpions, Physoctonus, Rhopalurus, and Troglorhopalurus, revalidation of Heteroctenus, and descriptions of two new genera and three new species (Buthidae, Rhopalurusinae). (Bulletin of the American Museum of Natural History, no. 415)". hdl:2246/6723. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: multiple names: authors list (link)
^Yoder, Jeremy B.; Mattheis, Allison (2015-08-04). "Queer in STEM: Workplace Experiences Reported in a National Survey of LGBTQA Individuals in Science, Technology, Engineering, and Mathematics Careers". Journal of Homosexuality. 63 (1): 1–27. doi:10.1080/00918369.2015.1078632. ISSN0091-8369. PMID26241115. S2CID4514344.