The line was constructed by the civil engineering partnership Peto, Brassey and Betts for the Danish state. The section from Langå to Viborg opened on 21 July 1863.[4] The section from Viborg to Skive opened on 17 October 1864 and the section from Skive to Struer on 17 November 1865.[5] The construction was influenced by the Second Schleswig War in 1864 which delayed the opening of the sections west of Viborg.[2]
In 2003, operation of the regional rail services on the Langå-Struer Line were transferred from DSB to the public transport company Arriva.[1]