In 2013, Adofo-Mensah began his NFL career with the San Francisco 49ers – under general manager Trent Baalke and head coach Jim Harbaugh – following a chance meeting with the team's executive vice president of football operations and NFL cap and contract manager Paraag Marathe. As manager of football research and development, Adofo-Mensah developed under Marathe, who is renowned for his cap management work in the NFL.[3]
In 2017, Adofo-Mensah was retained under new general manager John Lynch and was promoted to director of football research and development.
Cleveland Browns
On May 15, 2020, Adofo-Mensah was hired by the Cleveland Browns as their vice president of football operations under general manager Andrew Berry.[4][5]
Minnesota Vikings
On January 26, 2022, Adofo-Mensah was hired as the general manager of the Minnesota Vikings.[6][7]