Powell was the Producing Artistic Director of Contemporary Stage Company, a summer theater in Wilmington, Delaware.[5] His producing credits include New York productions of The Mouse That Roared, Enter Pissarro, Indra & Agni Collide and a workshop of Kidding Jane with Ellen McLaughlin and William Charles Mitchell. Powell was the resident director for Equalogy, a professional touring company promoting social change, for which he directed two plays by August Schulenberg, Four Hearts Changing and One Night.
His other directing credits include Dutchman, Quality of Silence, The Visit and Enter Pissarro. As an actor, Powell has appeared in numerous national network commercials. His theatre credits include Romeo & Juliet (The Shakespeare Theatre, Washington, D.C.), Kidding Jane (Portland Stage Company), Macbeth (Pittsburgh Public Theater), As Bees in Honey Drown (Hangar Theater, Ithaca, New York), and The French (HB Playwrights Foundation, NYC) among others.[1]
In the spring of 2007, while working as a recurring character on 30 Rock, he shot an ABC pilot called Judy's Got A Gun.[6] It was not picked up for the Fall 2007 season, and Powell returned to 30 Rock, where he was promoted to a series regular. In October 2008, Powell launched and starred in a self-funded web series called Keith Powell Directs a Play (co-written and directed by Patrick Flynn[7]), chronicling Powell's foray into directing Uncle Vanya at a fictional repertory theatre group.[8] In 2009, Powell was a guest commentator on VH1's 100 Greatest One Hit Wonders of the 80s, and also played a Tuskegee Airman in Night at the Museum: Battle of the Smithsonian.
In 2014, Powell began a recurring role on the television series About a Boy as Richard, Will's workaholic friend, accountant, and business manager.[9]
Powell recurred on the final season of The Newsroom.[10] He appeared in the feature film My Name Is David. In 2015, he created, wrote, directed, and starred in the web series Keith Broke His Leg. The series went on to win several Indie Series Awards, including Best Comedy Series and Best Actor in a Comedy.[11]
In October 2013, Powell married visual artist Jill Knox.[13][14] In 2019, Powell and Knox announced the birth of their first child, a daughter.[15] In 2021, they had a second child, a boy. Powell and Knox live in Los Angeles.