American biochemist
Katrina Miranda is an associate professor of biochemistry at the University of Arizona . She works on nitric oxide and their role in diseases like breast cancer , stroke and chronic pain .
Early life and education
Miranda studied chemistry at Northern Arizona University .[ 1] She moved to the University of California, Santa Barbara , and earned her PhD in 1996.[ 1] Miranda was a postdoctoral fellow at the University of New Mexico School of Medicine .[ 1]
Research
Miranda studies the chemical and biological basis of redox signalling agents.[ 1] [ 2] She was a National Institutes of Health postdoctoral fellow at the National Cancer Institute from 1998 to 2002, before joining the University of Arizona .[ 3] She looks to identify the biomarkers of disease development. They do this by investigating the molecular redox chemistry new donor systems and designing ways to detect biological signals.[ 1] [ 4] [ 5] Nitric oxide is synthesised in the body when L-Arginine enzymatically oxidises.[ 6] Miranda looked at what happens when nitric oxides accumulate, including their impact on chronic pain, strokes and breast cancer.[ 7] She demonstrated that nitric oxide can modify how enzymes bind to metal centres.[ 6] She studied the reactivity of azanone to clarify the activity of biomolecules.[ 8] She published the textbook Chemical Biology of Nitric Oxide in 2008.[ 9] Her research group attach chemical moieties that can improve drug delivery.[ 1] They are using gene expression, genomic and proteomic techniques to analyse the cellular effects of redox active signalling.[ 1]
Miranda runs outreach activities for faculty at the Arizona Community College to take part in research in her faculty.[ 8] In 2013 she developed a massive open online course with Google that would explain abstract chemistry concepts to students around the world.[ 10] In 2018 she filed a class action lawsuit against the University of Arizona for gender discrimination against women professors.[ 11] She is not the first to sue the University of Arizona ; emeritus dean Patricia MacCorquodale and former dean Janice Cervelli took them to court on behalf of women deans in early 2018.[ 12]
Awards
References
^ a b c d e f g h i j "Katrina Miranda | cbc.arizona.edu" . cbc.arizona.edu . Archived from the original on 2019-02-06. Retrieved 2018-12-11 .
^ Vázquez-Torres, Andrés (November 2012). "Redox Active Thiol Sensors of Oxidative and Nitrosative Stress" . Antioxidants & Redox Signaling . 17 (9): 1201– 1214. doi :10.1089/ars.2012.4522 . ISSN 1523-0864 . PMC 3430479 . PMID 22257022 .
^ a b Blue, Alexis; Communications, University (5 January 2009). "Chemistry Professor Honored in Washington, D.C." UANews . Retrieved 2018-12-11 .
^ Cheng, Robert Y.S.; Basudhar, Debashree; Ridnour, Lisa A.; Heinecke, Julie L.; Kesarwala, Aparna H.; Glynn, Sharon; Switzer, Christopher H.; Ambs, Stefan; Miranda, Katrina M. (December 2014). "Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways" . Nitric Oxide . 43 : 17– 28. doi :10.1016/j.niox.2014.08.003 . ISSN 1089-8603 . PMC 4250314 . PMID 25153034 .
^ Johnson, Gail M.; Chozinski, Tyler J.; Gallagher, Elyssia S.; Aspinwall, Craig A.; Miranda, Katrina M. (November 2014). "Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors" . Free Radical Biology and Medicine . 76 : 299– 307. doi :10.1016/j.freeradbiomed.2014.07.022 . ISSN 0891-5849 . PMC 4254043 . PMID 25064322 .
^ a b "Katrina M-Miranda | BIO5" . www.bio5.org . Archived from the original on 2018-12-14. Retrieved 2018-12-11 .
^ "Developing Anticancer Drugs | Benefunder" . www.benefunder.com . Archived from the original on 2018-12-14. Retrieved 2018-12-11 .
^ a b "The Presidential Early Career Award for Scientists and Engineers: Recipient Details | NSF - National Science Foundation" . www.nsf.gov . Retrieved 2018-12-11 .
^ Miranda, Katrina (2008-03-31). Chemical Biology of Nitric Oxide (1st ed.). Garland Science. ISBN 9780815341475 .
^ "The University of Arizona Foundation - Gift Impact Article" . www.uafoundation.org . Archived from the original on 2018-12-14. Retrieved 2018-12-11 .
^ December 2018, Rebecca Trager11. "Chemistry prof sues for $20m over alleged gender discrimination" . Chemistry World . Retrieved 2018-12-11 . {{cite web }}
: CS1 maint: numeric names: authors list (link )
^ "U of Arizona is being sued once again for alleged discrimination against women in terms of salary and promotions" . www.insidehighered.com . Archived from the original on 2018-12-07. Retrieved 2018-12-11 .
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External links