Halbreich was director of the Albert and Vera List Visual Arts Center at MIT, where she designed a new arts building with architect I.M. Pei. She was then the curator of contemporary art at the Museum of Fine Arts, Boston.[2]
In 1991, Halbreich was hired as director of the Walker Art Center. Under her leadership, the museum broadened its reputation for developing emerging talent, hosting avant-garde performances and exhibitions. She oversaw a $73.8 million expansion at the Walker and announced her retirement in 2007.[3] She was hired as an associate director of the Museum of Modern Art in 2008.[2][4] At MoMA, Halbreich curated a 2014 retrospective of German artist Sigmar Polke and a 2018 Bruce Nauman exhibition.[5][6]
In September, 2017 Halbreich was appointed director of the Robert Rauschenberg Foundation.[7]