KO began their professional career in 1997 when they joined the original Broadway production of Rent. They joined as a replacement swing, also understudying the roles of Mimi and Maureen. The following year they joined the first national tour of Rent, dubbed the "Angel Tour", as a replacement swing once again. In late 1998, KO began playing Mimi on the tour, and they continued in the role until leaving the show in January 1999. They moved back to New York City in 1999[4] but did not receive any roles outside of a small part in As the World Turns before joining the regional try-out of the musical Brooklyn in 2003.[6][7] Before Brooklyn transferred to Broadway the following Fall, KO took part of a regional staging of Children of Eden and filmed guest roles for All My Children and Law & Order.[8] The musical Brooklyn open on Broadway in October 2004 and closed in June 2005.[9] Following its closure, KO joined the cast of the Brazilian-themed off-Broadway musical Miracle Brothers, which closed in October 2005.[10] The following year they had small roles in NBC's Conviction and the independent film Adrift in Manhattan, which premiered at the Sundance Film Festival in 2007.
In 2009, KO won a Tony Award for their performance as Anita in the Broadway revival of West Side Story.[11] They were also nominated for both a Drama Desk and an Outer Critic's Circle Award for their critically acclaimed performance as Anita. They earned their second Astaire Award nomination for Best Female Dancer for their performance in West Side Story, after previously winning the same award in 2008 for their performance in In the Heights. They were contracted with West Side Story at the Palace through 2010.[12] During the May 8, 2010, matinee performance of West Side Story, KO broke their foot.[13] Anita standby Natalie Cortez performed the role until the show's closure.[14]
KO then took part in the world premiere of By the Way, Meet Vera Stark at off-Broadway's Second Stage Theater. Written by Pulitzer Prize-winning playwright Lynn Nottage, the play "draws upon the screwball films of the 1930s to take a funny and irreverent look at racial stereotypes in Hollywood."[15]
Film and television
KO had a recurring role in The Good Wife on CBS. They played wealthy law student Giada Cabrini, a potential love interest of firm partner Will Gardner (Josh Charles). KO was a series regular in the second season of NBC's Harry's Law, playing "hot shot lawyer" Cassie Reynolds hired by Kathy Bates' character.[16]
KO also appeared as Isabelle Perez, a woman who was unknowingly sterilized in the Law & Order episode "Birthright". They also appear in the spin-off series Law & Order: Special Victims Unit as Jennifer Benitez in an episode titled "Loophole". They later appeared in Law & Order: Special Victims Unit as Yelina Muñoz in an episode titled "October Surprise".
KO has had several roles in movies, including Make Yourself at Home, The New Twenty, Shanghai Hotel, and The Orphan Killer.
2013–present: Break from acting and return to theater
On March 18, 2013, KO announced on their website that they were taking a break from acting, saying "with this knowledge I start a new chapter. I leave behind the actor and I start learning how to be me."[17][18][19] During this period, they moved to Madison, Wisconsin, where they taught classes for the UW–Madison theater department and became involved in the local theater scene, which included opening a private studio to coach young performers.[20]
On July 13, 2016, it was announced that KO would star as Angelica Schuyler in the Chicago production of Hamilton.[22] They were part of the cast from October 19, 2016, until August 6, 2017. They stated they intended to pursue teaching after leaving the production, stating that "I'm leaving the spotlight to make sure others find theirs". In February 2018, KO played Florence Vassy in the Kennedy Center's revival of the musical Chess.
Moulin Rouge!
On July 25, 2019, KO starred in the premiere of the Broadway production of the jukebox musical Moulin Rouge! in New York City. They continued to perform their role in the show at the Al Hirschfeld Theatre for an open-ended run.[23] On October 15, 2020, KO was nominated for a Tony Award for Best Leading Actress in a Musical.[24] On April 14, 2021, KO announced they would not return to the show once it reopens as a protest of the industry's silence on the allegations against producer Scott Rudin. In an Instagram video, KO stated, "Social justice is more important than being the sparkling diamond."[25]
In December 2021, KO joined We Won't Sleep, a bio-musical based on the life of Jeannette Rankin. Industry readings of the production took place on December 17 and 18, 2021 in New York City.[26] The world premiere was set to open in May 2022 at Signature Theatre in Arlington, Virginia, but was cancelled due to the COVID-19 pandemic.[27]
Podcasts
On July 18, 2021, KO appeared on a podcast entitled Noah's Corner, previously Rye's Little Corner, on episode 19, titled "Dreams Come True Bitches".[28] On the episode, Karen was interviewed by co-hosts Noah Grace and Nellie. They spoke about their time in In the Heights and Moulin Rouge! as well as their album, Leave.[29]
Northwestern University
In 2022, KO relocated to Evanston, IL to work as an associate professor at Northwestern University, where they serve as the head of music theatre.
Personal life
KO is married to Jim Uphoff, with whom they have two step-children. KO and Uphoff, a marketing manager and former New York theater sound technician, married in September 2014.[20][4] Until 2012, KO was married to Broadway actor Matt Caplan.
In 2013, while taking a break from acting, KO moved to Madison, Wisconsin, where they and Uphoff share a home they call their "home base".[4] Both KO and their husband have family in Madison.[30] KO has previously lived in Hell's Kitchen, Manhattan, Brooklyn, and Los Angeles.[4][20][18]
