The station originally broadcast under the call letters KUMR, from the abbreviation of the station's home, the University of Missouri–Rolla, through 2006. On January 1, 2008, the University of Missouri–Rolla changed its name to Missouri University of Science and Technology.[2] As a result, the station's original call sign, KUMR, was changed to KMST on July 16, 2007, as a reflection of the university's forthcoming name change.[3]
Until 2017, KMST broadcast from studios in the basement of the Curtis Laws Wilson library on the UMR/Missouri S&T campus. Effective July 1, 2017, the station (including its Lebanon translator) was transferred to the University of Missouri-St. Louis and became part of the St. Louis Public Radio network, airing the same broadcast as the St. Louis frequency.[4] The only local programming retained through the changeover was Wayne Bledsoe's Bluegrass for a Saturday Night, a local staple for many decades,[5] which continued until Bledsoe's August 2017 retirement.[6] Missouri S&T opted to end KMST's local operations after the University of Missouri system suffered a massive budget cut that led school officials to conclude KMST was no longer part of the school's "academic core."[7]
KMST was also heard in Lebanon, Missouri via translator K242AN on 96.3 MHz FM, until the translator went silent in August 2020; its license was cancelled by the Federal Communications Commission on March 28, 2022.