KLHDC3

KLHDC3
Identifiers
Aliases	KLHDC3, PEAS, dJ20C7.3, kelch domain containing 3
External IDs	OMIM: 611248; MGI: 2651568; GeneCards: KLHDC3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,021,298 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,991,840 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right frontal lobe; ; prefrontal cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; muscle of thigh; ; Brodmann area 9; ; triceps brachii muscle; ; nucleus accumbens;
	Top expressed in
	seminiferous tubule; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; right ventricle; ; muscle of thigh; ; yolk sac; ; temporal muscle; ; ankle; ; secondary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding;
Cellular component	cytoplasm; cytosol; nucleoplasm;
Biological process	reciprocal meiotic recombination; IRE1-mediated unfolded protein response; meiosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	116138
	71765
	ENSG00000124702
	ENSMUSG00000063576
	Q9BQ90
	Q8VEM9
	NM_001242872; NM_057161
	NM_001163729; NM_027910
	NP_476502
	NP_001157201; NP_082186
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.^[5]^[6]

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasm and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124702 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063576 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohinata Y, Sutou S, Kondo M, Takahashi T, Mitsui Y (Nov 2002). "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis". Biol Reprod. 67 (6): 1824–31. doi:10.1095/biolreprod.101.002550. PMID 12444059.
^ ^a ^b "Entrez Gene: KLHDC3 kelch domain containing 3".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ohinata Y, Sutou S, Mitsui Y (2003). "Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals". DNA Res. 10 (2): 79–84. doi:10.1093/dnares/10.2.79. PMID 12755172.
Ohinata Y, Sutou S, Mitsui Y (2003). "A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin". FEBS Lett. 537 (1–3): 1–5. doi:10.1016/S0014-5793(03)00036-X. PMID 12606021. S2CID 45307604.
Hermey G, Keat SJ, Madsen P, et al. (2003). "Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells". J. Biol. Chem. 278 (9): 7390–6. doi:10.1074/jbc.M210851200. PMID 12482870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124702 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063576 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12444059-5] Ohinata Y, Sutou S, Kondo M, Takahashi T, Mitsui Y (Nov 2002). "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis". Biol Reprod. 67 (6): 1824–31. doi:10.1095/biolreprod.101.002550. PMID 12444059.

[entrez-6] "Entrez Gene: KLHDC3 kelch domain containing 3".

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KLHDC3

References

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