KIAA1333

G2E3

Identifiers

G2E3, KIAA1333, PHF7B, G2/M-phase specific E3 ubiquitin protein ligase

External IDs

OMIM: 611299; MGI: 2444298; HomoloGene: 32362; GeneCards: G2E3; OMA:G2E3 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q12	Start	30,559,158 bp^[1]
Band	14q12	End	30,620,064 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 B3	Start	51,394,844 bp^[2]
Band	12\|12 B3	End	51,423,769 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sperm

testicle

gonad

ventricular zone

right testis

left testis

ganglionic eminence

pancreatic epithelial cell

epithelium of colon

Achilles tendon

Top expressed in

hand

Rostral migratory stream

superior cervical ganglion

epiblast

tail of embryo

genital tubercle

primitive streak

maxillary prominence

medial ganglionic eminence

spermatid

More reference expression data


More reference expression data

Gene ontology
Molecular function	ubiquitin-protein transferase activity protein binding metal ion binding transferase activity
Cellular component	cytoplasm nucleolus nucleus cytosol intracellular membrane-bounded organelle
Biological process	multicellular organism development protein ubiquitination apoptotic process
Sources:Amigo / QuickGO

Species

Human

Mouse


55632


217558


ENSG00000092140


ENSMUSG00000035293


Q7L622


Q5RJY2

RefSeq (mRNA)


NM_001308097 NM_017769


NM_001015099 NM_001167963 NM_001167964

RefSeq (protein)


NP_001295026 NP_060239


NP_001015099 NP_001161435 NP_001161436

Location (UCSC)

Chr 14: 30.56 – 30.62 Mb

Chr 12: 51.39 – 51.42 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

G2/M phase-specific E3 ubiquitin-protein ligase is an enzyme that in humans is encoded by the G2E3 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092140 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035293 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA, Crawford DF (Aug 2008). "G2E3 is a dual function ubiquitin ligase required for early embryonic development". J Biol Chem. 283 (32): 22304–15. doi:10.1074/jbc.M803238200. PMC 2494922. PMID 18511420.
^ Brooks WS, Banerjee S, Crawford DF (Feb 2007). "G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization". Exp Cell Res. 313 (4): 665–76. doi:10.1016/j.yexcr.2006.11.020. PMC 1876774. PMID 17239372.
^ "Entrez Gene: KIAA1333 KIAA1333".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Crawford DF, Piwnica-Worms H (2001). "The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators". J. Biol. Chem. 276 (40): 37166–77. doi:10.1074/jbc.M103414200. PMID 11483598.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

v t e KIAA human genes
KIAA0020 KIAA0101 KIAA0157 KIAA0174 KIAA0182 KIAA0196 KIAA0243 KIAA0274 KIAA0319 KIAA0368 KIAA0409 KIAA0430 KIAA0460 KIAA0515 KIAA0802 KIAA0859 KIAA0895 KIAA0999 KIAA1012 KIAA1109 KIAA1166 KIAA1199 KIAA1219 KIAA1267 KIAA1279 KIAA1303 KIAA1333 KIAA1377 KIAA1524 KIAA1539 KIAA1683 KIAA1826 KIAA1949 KIAA1967

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