After her PhD and during her postdoctoral research, Biggs started working with satellite imagery to understand tectonic and volcanic regions.[5][6]
In 2010, Biggs joined the University of Bristol, where she was made a full professor in 2019.[citation needed] Her research investigates earthquakes and the earthquake cycle. She has studied dyke intrusions in the East African Rift and the development of new hazard assessments. Biggs has used satellite imagery to understand volcanoes all around the world, and has identified that several volcanoes previously considered dormant are in fact evolving rapidly.[5][7] She proposed that this imaging approach could be used to forecast volcanoes that were at risk of eruption.[8] She used imagery from the Sentinel-1 to understand deformation around Mount Agung.[9] In 2020, she was awarded a European Research Council Consolidator Grant to image volcanoes using 'strain tomography'.[10]