Following a stint as Vice Minister of Health for the Province of San Luis, in 2002 he was named Public Health Secretary of the District of La Matanza, a western, mainly blue-collar suburb of the Argentine capital. Recommended by the National Health Minister, Ginés González García, Manzur was appointed Health Minister of Tucumán Province by the new Governor, José Alperovich, in 2003. Manzur soon earned plaudits in his post, which oversaw public health in one of Argentina's least-developed provinces.[3] One widely used yardstick of public health, the infant mortality rate, fell from 23 per 1,000 births (40% above the national average) in 2003, to 13 in 2006 (matching the national average).[4][5] The perinatal mortality rate (a late fetal death, or of an infant under one week old) likewise fell during the same period in Tucumán from 24 to 18 per 1,000 births.[4][6] These news helped Manzur secure Governor Alperovich's nod to be a running mate for his successful, 2007 bid for re-election.
He stepped down as Health Minister in February 2015 to return to the post of Vice Governor of Tucumán, and was expected to run to succeed Governor Alperovich in provincial elections later in the year.[11]