Du Pré was born in South Carolina, the son of Cornelius Dupré. He joined the civil service of the East India Company in 1752, as a factor, and rose through a succession of positions. He spent a period in England in the 1760s, and married there.[1] He purchased the Wilton Park Estate near Beaconsfield in Buckinghamshire from the Basil family in 1760,[2] or around 1770.[3]
Du Pré was Governor of Madras from 1770 to 1773. He was mostly preoccupied with the construction of fortifications there. His authority was circumscribed: Eyre Coote, the military commander, and Sir John Lindsay who had overall command in the East Indies, left him little room in which to operate.[1]
Once back in England he commissioned Richard Jupp to build a mansion at Wilton Park. Known as the "White House", it was completed in 1779.[4]