Escobar served as Bishop of San Vicente beginning in 2005, prior to his elevation to San Salvador on 27 December 2008. He was previously an auxiliary bishop in the Diocese of San Vicente since 2002, having entered the priesthood in 1982.
In late December 2012, Escobar authorised the removal of the tiled ceramic mural façade of the San Salvador Cathedral, El Salvador's principal basilica, without consultation with the national government nor the artist, Fernando Llort. This resulted in the destruction of all the 2,700 tiles of the mural which depicted former archbishop Óscar Romero.[2]