DeLuca made his professional debut with the rookie-level Arizona League Dodgers in 2019, where he hit .273 in 26 games.[5] DeLuca did not play in a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.[6] He returned to action in 2021 to play for the Single-A Rancho Cucamonga Quakes and High-A Great Lakes Loons, hitting a combined .264 in 101 games with 22 home runs and 64 runs batted in (RBIs).[5] DeLuca started the 2022 season with Great Lakes before being promoted to the Double-A Tulsa Drillers. Between the two levels, he played in 98 games and hit .260 with 25 home runs and 71 RBIs.[5]
On November 15, 2022, the Dodgers added DeLuca to the 40-man roster to protect him from the Rule 5 draft.[7] He returned to Tulsa to begin the 2023 season[8] and was promoted to the Triple-A Oklahoma City Dodgers on May 16.[9] After just 17 games there, he was called up to the majors for the first time on June 4.[10] DeLuca made his debut against the Cincinnati Reds on June 7 as the starting centerfielder.[11] He was hitless in two at-bats with a walk in his debut.[12] His first major league hit was a single to center field off of Ranger Suárez of the Philadelphia Phillies on June 9.[13] On July 4, 2023, DeLuca hit his first MLB home run off Ángel Perdomo of the Pittsburgh Pirates.[14] He played in a total of 24 games in the majors, hitting .262 with two homers and six RBIs before being optioned back to the minors.[15] Between the two minor league levels he played at in 2023, he appeared in 73 games and hit .294 with 17 homers and 53 RBI.[5]