Jonathan Marchini

Jonathan Marchini
Born
Jonathan Laurence Marchini

Chichester
NationalityBritish
Alma mater
Awards
Scientific career
Institutions
Thesis The Statistical Analysis of Brain Images  (2002)
Doctoral advisorBrian Ripley[2]
Websitejmarchini.org

Jonathan Laurence Marchini (born 19 May 1973)[3] is a Bayesian statistician and professor of statistical genomics[4] in the Department of Statistics at the University of Oxford, a tutorial fellow in statistics at Somerville College,[5] Oxford and a co-founder and director of Gensci Ltd.[6] He co-leads the Haplotype Reference Consortium.[7]

Education

He obtained a Bachelor of Science degree in Pure Mathematics and Mathematical Statistics from Exeter University (1991–94).[8] He then obtained a PGCE in Mathematics Education from the West Sussex Institute of Higher Education (1994–95). He completed his DPhil in the Department of Statistics at the University of Oxford supervised by Professor Brian Ripley (1998–2002).[9]

Career and research

Marchini spent three years working as a VSO volunteer teaching A-level Mathematics at Tosamaganga Secondary school, near Iringa, Tanzania, between September 1995 and September 1998.[10]

From 2002 to 2005 he held a Wellcome Trust Training Fellowship in Mathematical Biology, under the supervision of Prof Lon Cardon and Prof Peter Donnelly.

In 2006 he was appointed as a university lecturer (associate professor) in statistical genomics in the Department of Statistics at the University of Oxford and a senior research fellow at Mansfield College. In 2007 he became an affiliated group leader at the Wellcome Trust Center of Human Genetics[11] at the University of Oxford. In 2010 he was re-appointed until retirement [12]

In 2015 he was promoted to professor of statistical genomics[13][14]

Marchini's research focusses on statistical genetics and population genetics, with a particular emphasis on methods development for genome-wide association studies. He has worked on haplotype estimation,[15][16][17][18] genotype imputation,[19] genotype calling from arrays and sequencing, sparse tensor decomposition for RNA-seq datasets,[20] population structure,[21] phenotype prediction and mixed models,[22] gene–gene interactions[23] and brain imaging genetics.[24]

He was a member of the analysis team for the International HapMap Project, the Wellcome Trust Case-Control Consortium, the 1000 Genomes Project and the UK10K Project. His research group was responsible for the haplotype estimation and genotype imputation for the UK Biobank dataset. He co-leads the Haplotype Reference Consortium.[25]

He has been an ISI Highly Cited Researcher from 2014-2018[26]

He has acted as an expert witness in a patent trial[27]

Awards

In 2012 he was awarded a Philip Leverhulme Prize[28] for "leading the way by constructing powerful and ingenious novel statistical methodology for population and medical genetics, together with associated fast computational algorithms and software."

References

  1. ^ "Leverhulme website" (PDF). Archived from the original (PDF) on 2018-04-02. Retrieved 2018-04-01.
  2. ^ Marchini, J.; Ripley, B. (2000). "A New Statistical Approach to Detecting Significant Activation in Functional MRI. Molecular evolution". NeuroImage. 12 (4): 366–80. doi:10.1006/nimg.2000.0628. PMID 10988031. S2CID 54375337.
  3. ^ "Companies house record".
  4. ^ "Marchini website".
  5. ^ "Somerville website".
  6. ^ "Companies house record".
  7. ^ "HRC website".
  8. ^ "Somerville College Report" (PDF).
  9. ^ Marchini, Jonathan L.; Ripley, Brian D. (October 2000). "A New Statistical Approach to Detecting Significant Activation in Functional MRI". NeuroImage. 12 (4): 366–380. doi:10.1006/nimg.2000.0628. PMID 10988031. S2CID 54375337.
  10. ^ "Photo album".
  11. ^ "WTCHG website".
  12. ^ "Oxford Gazette link".
  13. ^ "Oxford Gazette link". Archived from the original on 2015-09-16. Retrieved 2018-04-01.
  14. ^ "Oxford Gazette link".
  15. ^ O'Connell, Jared; Sharp, Kevin; Shrine, Nick; Wain, Louise; Hall, Ian; Tobin, Martin; Zagury, Jean-Francois; Delaneau, Olivier; Marchini, Jonathan (6 June 2016). "Haplotype estimation for biobank-scale data sets". Nature Genetics. 48 (7): 817–820. doi:10.1038/ng.3583. PMC 4926957. PMID 27270105.
  16. ^ O'Connell, Jared; Gurdasani, Deepti; Delaneau, Olivier; Pirastu, Nicola; Ulivi, Sheila; Cocca, Massimiliano; Traglia, Michela; Huang, Jie; Huffman, Jennifer E.; Rudan, Igor; McQuillan, Ruth; Fraser, Ross M.; Campbell, Harry; Polasek, Ozren; Asiki, Gershim; Ekoru, Kenneth; Hayward, Caroline; Wright, Alan F.; Vitart, Veronique; Navarro, Pau; Zagury, Jean-Francois; Wilson, James F.; Toniolo, Daniela; Gasparini, Paolo; Soranzo, Nicole; Sandhu, Manjinder S.; Marchini, Jonathan; Gibson, Greg (17 April 2014). "A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness". PLOS Genetics. 10 (4): e1004234. doi:10.1371/journal.pgen.1004234. PMC 3990520. PMID 24743097.
  17. ^ Delaneau, Olivier; Howie, Bryan; Cox, Anthony J.; Zagury, Jean-François; Marchini, Jonathan (October 2013). "Haplotype Estimation Using Sequencing Reads". The American Journal of Human Genetics. 93 (4): 687–696. doi:10.1016/j.ajhg.2013.09.002. PMC 3791270. PMID 24094745.
  18. ^ Delaneau, Olivier; Zagury, Jean-Francois; Marchini, Jonathan (1 January 2013). "Improved whole-chromosome phasing for disease and population genetic studies". Nature Methods. 10 (1): 5–6. doi:10.1038/nmeth.2307. PMID 23269371. S2CID 205421216.
  19. ^ Howie, Bryan N.; Donnelly, Peter; Marchini, Jonathan; Schork, Nicholas J. (19 June 2009). "A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies". PLOS Genetics. 5 (6): e1000529. doi:10.1371/journal.pgen.1000529. PMC 2689936. PMID 19543373.
  20. ^ Hore, Victoria; Viñuela, Ana; Buil, Alfonso; Knight, Julian; McCarthy, Mark I; Small, Kerrin; Marchini, Jonathan (1 August 2016). "Tensor decomposition for multiple-tissue gene expression experiments". Nature Genetics. 48 (9): 1094–1100. doi:10.1038/ng.3624. PMC 5010142. PMID 27479908.
  21. ^ Marchini, Jonathan; Cardon, Lon R; Phillips, Michael S; Donnelly, Peter (28 March 2004). "The effects of human population structure on large genetic association studies". Nature Genetics. 36 (5): 512–517. doi:10.1038/ng1337. PMID 15052271.
  22. ^ Dahl, Andrew; Iotchkova, Valentina; Baud, Amelie; Johansson, Åsa; Gyllensten, Ulf; Soranzo, Nicole; Mott, Richard; Kranis, Andreas; Marchini, Jonathan (22 February 2016). "A multiple-phenotype imputation method for genetic studies". Nature Genetics. 48 (4): 466–472. doi:10.1038/ng.3513. PMC 4817234. PMID 26901065.
  23. ^ Marchini, Jonathan; Donnelly, Peter; Cardon, Lon R (27 March 2005). "Genome-wide strategies for detecting multiple loci that influence complex diseases". Nature Genetics. 37 (4): 413–417. doi:10.1038/ng1537. PMID 15793588. S2CID 5922358.
  24. ^ Elliott, Lloyd T.; Sharp, Kevin; Alfaro-Almagro, Fidel; Shi, Sinan; Miller, Karla; Douaud, Gwenaëlle; Marchini, Jonathan; Smith, Stephen (2018). "BioRxiv paper". doi:10.1101/178806. {{cite journal}}: Cite journal requires |journal= (help)
  25. ^ "HRC website".
  26. ^ "ISI Highly Cited Researchers".
  27. ^ "Illumina vs Premaitha".
  28. ^ "Leverhulme website" (PDF). Archived from the original (PDF) on 2018-04-02. Retrieved 2018-04-01.