He was the only son of William Wynne of Melai and educated at Jesus College, Oxford.
He was a common councilman for Denbigh from 1707 to his death, serving as mayor in 1712 and an alderman in 1715–16, 1717–18. He was pricked High Sheriff of Denbighshire for 1711–12 and was a Member of Parliament (MP) for Denbigh Boroughs from 1713 to 1715.