John R. Yates

John R. Yates
Alma materUniversity of Maine
University of Virginia
Known forMass Spectrometry
AwardsBiemann Medal (2004)
Ralph N. Adams Award in Bioanalytical Chemistry (2015)
ACS Award in Analytical Chemistry (2015)
John B. Fenn Award (2019)
Scientific career
FieldsChemist
InstitutionsThe Scripps Research Institute

John R. Yates III is an American chemist and Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology at The Scripps Research Institute in La Jolla, California. He is currently editor-in-chief of the Journal of Proteome Research. He appeared on list of 2022, 2023 and 2024 Highly Cited Researchers, making him among the top one percent of most cited researchers in the world.[1][2][3]

His work is focused on developing tools and in proteomics and he specializes in mass spectrometry. He is best known for the development of the Sequest algorithm for automated peptide sequencing[4][5] and Multidimensional Protein Identification Technology (MudPIT)[6] and data-independent acquisition.[7] His lab is known for its contribution to methods to identify structural changes in proteins in living cells as well as method to identify N-glycan processing and occupancy using mass spectrometry such as covalent protein painting,[8] and DeGlyPHER (Deglycosylation-dependent Glycan/Proteomic Heterogeneity Evaluation Report).[9] His laboratory has made important contributions to understanding the biochemical mechanisms behind the failure of △F508 cystic fibrosis ion transport regulator to mature.[10][11]

References

  1. ^ "13 Scripps Research faculty named to Highly Cited Researchers List". Scripps Research Magazine. Retrieved 2024-12-03.
  2. ^ "Scripps Research scientists make annual Highly Cited Researchers list". www.scripps.edu. Retrieved 2024-12-03.
  3. ^ "Numerous Scripps Research scientists named Highly Cited Researchers". www.scripps.edu. Retrieved 2024-12-03.
  4. ^ Eng, Jimmy K.; McCormack, Ashley L.; Yates, John R. (November 1994). "An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database". Journal of the American Society for Mass Spectrometry. 5 (11): 976–989. Bibcode:1994JASMS...5..976E. doi:10.1016/1044-0305(94)80016-2. ISSN 1044-0305. PMID 24226387.
  5. ^ The Invention of SEQUEST | Prof. John Yates III | SCP2018. Retrieved 2024-04-14 – via www.youtube.com.
  6. ^ Washburn, Michael P.; Wolters, Dirk; Yates, John R. (March 2001). "Large-scale analysis of the yeast proteome by multidimensional protein identification technology". Nature Biotechnology. 19 (3): 242–247. doi:10.1038/85686. ISSN 1087-0156. PMID 11231557. S2CID 16796135.
  7. ^ Venable, John D; Dong, Meng-Qiu; Wohlschlegel, James; Dillin, Andrew; Yates, John R (2004). "Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra". Nature Methods. 1 (1): 39–45. doi:10.1038/nmeth705. ISSN 1548-7091. PMID 15782151. S2CID 9780065.
  8. ^ Son, Ahrum; Pankow, Sandra; Bamberger, Tom Casimir; Yates, John R. (2023), "Quantitative structural proteomics in living cells by covalent protein painting", Methods in Enzymology, vol. 679, Elsevier, pp. 33–63, doi:10.1016/bs.mie.2022.08.046, ISBN 978-0-323-99264-0, PMC 10262296, PMID 36682868, retrieved 2024-12-03
  9. ^ Baboo, Sabyasachi; Diedrich, Jolene K.; Martínez-Bartolomé, Salvador; Wang, Xiaoning; Schiffner, Torben; Groschel, Bettina; Schief, William R.; Paulson, James C.; Yates, John R. III (2021-10-12). "DeGlyPHER: An Ultrasensitive Method for the Analysis of Viral Spike N-Glycoforms". Analytical Chemistry. 93 (40): 13651–13657. doi:10.1021/acs.analchem.1c03059. ISSN 0003-2700. PMC 8848675. PMID 34597027.
  10. ^ Pankow, Sandra; Bamberger, Casimir; Calzolari, Diego; Martínez-Bartolomé, Salvador; Lavallée-Adam, Mathieu; Balch, William E.; Yates, John R. (2015-12-24). "∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis". Nature. 528 (7583): 510–516. Bibcode:2015Natur.528..510P. doi:10.1038/nature15729. ISSN 0028-0836. PMC 4826614. PMID 26618866.
  11. ^ Pankow, Sandra; Bamberger, Casimir; Yates, John R. (2019). "A posttranslational modification code for CFTR maturation is altered in cystic fibrosis". Science Signaling. 12 (562): eaan7984. doi:10.1126/scisignal.aan7984. ISSN 1945-0877. PMC 6464640. PMID 30600261.


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