In the 2015 NFL draft, Iosefa was selected by the Tampa Bay Buccaneers in the seventh round (231st overall).[2] He was waived on August 30, 2015, as part of Tampa Bay's final roster cutdowns.[3]
New England Patriots
The New England Patriots signed Iosefa to their practice squad on October 21, 2015.[3] On December 19, 2015, he was promoted to the Patriots' active roster.[4] He made his NFL debut on December 20, 2015, in the Patriots' 33–16 win over the Tennessee Titans. Iosefa racked up 51 yards on 14 carries to lead the Patriots in rushing yards for the game.[5] On December 28, 2015, he was waived by the Patriots.[3] On December 30, 2015, he was signed to the Patriots' practice squad.[6]
On January 26, 2016, Iosefa signed a futures contract with the Patriots.[7] He was released by the Patriots on May 6, 2016, but was re-signed on May 13.[8][9] On September 3, 2016, he was released by the Patriots as part of final roster cuts.[10]