The Indians purchased Colón's contract and added him to the 40-man roster on July 2, 2016. The Indians promoted Colón to the major leagues on July 7.[6]
On July 1, 2017, Colón was suspended for the remainder of the 2017 season after testing positive for a banned substance.[7] The Indians designated Colón for assignment on October 2, 2017, and outrighted him to the Triple-A Columbus Clippers on October 6, 2017. He elected free agency following the season on November 6.[8]
St. Louis Cardinals
On February 19, 2018, Colón signed a minor league deal with the St. Louis Cardinals. [9] He was released on March 28, 2018.
Bravos de León
On June 22, 2018, Colón signed with the Bravos de León of the Mexican League. He became a free agent after the season.