Jesse Stone may refer to:

• Jesse Stone (musician) (1901–1999) was an American musician and songwriter, also known as Charles Calhoun.
• Jesse Stone (Wisconsin politician) (born 1836), Lieutenant Governor of Wisconsin from 1899 to 1903
• Jesse Stone (Georgia politician) (born 1956), state senator from Georgia (U.S. state)
• Jesse N. Stone (1932–2001), civil rights attorney and judge in Louisiana and president of the Southern University System from 1974 to 1985

• Jesse Stone (character), a protagonist in a series of novels by Robert B. Parker, and the film adaptations:
  • Jesse Stone: Stone Cold (2005)
  • Jesse Stone: Night Passage (2006)
  • Jesse Stone: Death in Paradise (2006)
  • Jesse Stone: Sea Change (2007)
  • Jesse Stone: Thin Ice (2009)
  • Jesse Stone: No Remorse (2010)
  • Jesse Stone: Innocents Lost (2011)
  • Jesse Stone: Benefit of the Doubt (2012)
  • Jesse Stone: Lost in Paradise (2015)

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