Clarke was promoted to chief executive officer and president of Cendant's travel distribution services in April 2006.[5] Clarke next served as the Chairman of Travelport, Inc., a private, travel technology firm, where he served as CEO from 2006 to 2011, after leading its sale from Cendant Corporation to the Blackstone Group for US$4.3 billion in 2006.[6]
As Travelport CEO, he reorganized the company around three brands, engineered the acquisition of Worldspan and coordinated the sale of Orbitz Worldwide in an initial public offering on July 20, 2007.[7][8]
On March 12, 2014, he was named CEO and member of the Board of Directors of Kodak.[9][10][11] While CEO at Kodak, Clarke partnered with film directors and Quentin Tarantino, Martin Scorsese and J.J. Abrams to spearhead an effort protecting the use of celluloid film in the Motion Picture Industry.[12] Clarke announced his departure from Kodak on February 20, 2019.[13]
Clarke was announced on November 13, 2017, as having joined the Docker board of directors.[14]
Clarke was announced on August 23, 2019, as having joined FTD LLC as the new Executive Chairman.[1]
Clarke has also served on the Geneseo Foundation Board of Directors, where he delivered the address for the college's 145th undergraduate commencement.[22] Clarke is a member of the Board of Trustees of Northeastern University.[23]