Jean Holmes-Mitchell (born 7 November 1940) is a Panamanian sprinter. She competed in the women's 100 metres at the 1960 Summer Olympics. She finished second in the 1959 Pan American Games 4 × 100 metres Relay (with Carlota Gooden, Marcela Daniel, and Silvia Hunte). At the 1963 Pan American Games Holmes finished fourth in the 100 metres event.^[1]

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