Her early work included television guest roles on ER, Sports Night, The Adventures of Brisco County, Jr., and Murder, She Wrote. Starting in 1999, Moloney had a main role on The West Wing as Donna Moss, beginning as an assistant to Deputy White House Chief of Staff Josh Lyman (Bradley Whitford) before pursuing further ambitions in the next election.[4] Moloney was originally credited only as a guest star, but she appeared in every episode of the first season. From the second season onward, Moloney was listed in the main credits. She has received two Emmy Award nominations, one in 2002 and one in 2004, for Outstanding Supporting Actress in a Drama.[5][6]
Moloney appeared in the television film Bang Bang You're Dead with Thomas Cavanagh and Randy Harrison, which was first broadcast on October 13, 2002, on Showtime.[7] She played the part of Amber Frey in the made-for-TV movie Amber Frey: Witness for the Prosecution, broadcast May 25, 2005 on CBS.[8] In 2007, Moloney played Dana Chase, who has a relationship with Tommy Caffee (Jason Clarke) in six episodes of the second season of Brotherhood. [9]
In 2008, Moloney appeared in one episode ("It's a Wonderful Lie") of House M.D.[10] In 2008, she guest-starred in an episode of 30 Rock. Moloney appeared in the 3rd installment of the Lstudio.com web series Puppy Love.
In 2009, she appeared in the US series Life on Mars as Professor Pat Olsen in the episode "Revenge of the Broken Jaw". She also appeared in the episode "Faithfully" of Law & Order: Criminal Intent as Allison Wyler.
Moloney had a recurring role in the first season of HBO drama The Leftovers, and was bumped up to a main role for the following two seasons (2014-2017).
Moloney starred in the 2010 feature film Armless, as Anna.[13] She made a brief appearance as Earlene in the 1995 Walter Hill directed western Wild Bill, and appears in the 2013 film Concussion.
^"Almanac: On This Date; Today's Birthdays". Pittsburgh Post-Gazette. October 3, 2002. p. 2. ProQuest1871709775. Rock musician Tommy Lee is 40. Actress Janel Moloney ("The West Wing") is 33. Singer Gwen Stefani ("No Doubt") is 33.
^"Today in History: October 3; Today's Birthdays". Telegraph Herald. October 3, 2022. pp. A3. ProQuest721065571. Rock musician Tommy Lee is 60. Actor Clive Owen is 58. Actor Janel Moloney is 53. Singer Gwen Stefani (No Doubt) is 53.