James Mortimer may refer to:

• James Mortimer (chess player) (1833–1911), American/British chess player, journalist, and playwright
• James Mortimer (dogshow judge) (1842–1915), British dogshow judge
• Jim Mortimer (1921–2013), British trade unionist and General Secretary of the Labour Party
• William James Mortimer (died 2010), publisher, president and editor of the Deseret News
• James Mortimer (hurdler) (born 1983), New Zealand hurdler
• James Mortimer, a character in The Hound of the Baskervilles

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