James Gunn (born 1966) is an American filmmaker.

James Gunn may also refer to:

• James E. Gunn (1923–2020), American science fiction scholar and writer
• James Andrew Gunn, British medical doctor, founder of the British Pharmacological Society
• James Gunn (astronomer) (born 1938), American astronomer
• James Gunn (explorer) of Scotland, member of Henry Sinclair's survey expedition
• James Gunn (Idaho politician) (1843–1911), American congressman from Idaho
• James Gunn (Georgia politician) (1753–1801), United States senator from Georgia
  • SS James Gunn, a Liberty ship
• James Gunn (Australian politician), Tasmanian politician from the electoral district of Sorell (1872–1882)
• James Gunn (screenwriter) (1920–1966), American film and television screenwriter

• Herbert James Gunn (1893–1964), Scottish landscape and portrait painter

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