He was among the first physicians to give a detailed description of exophthalmic goitre, currently known as Graves disease (previously called Basedow's syndrome or Begbie's disease). He is also related to the study of Dubini's disease, the old name for myoclonicepidemic encephalitis.[1]
Begbie was born on 18 December 1798 in Edinburgh, and educated at the High School.[2] Aged 14 he was apprenticed to Dr John Abercrombie (1780–1844) at 19 York Place.[3] Later on, he also became Abercrombie's assistant.[2]
In 1847, he also became a fellow of the Royal College of Physicians, and became its president from 1854 up to 1856. For forty years, Begbie was a physician for the Scottish Widows Fund and Life Assurance Society 1837 to 1869.[2] In 1848 he was elected a member of the Aesculapian Club.[8]
Begbie's final years were spent living at 10 Charlotte Square one of Edinburgh's most prestigious addresses.[10] His neighbour was James Syme.
For several years he was Physician in Ordinary to Queen Victoria in Scotland.
Begbie died in Edinburgh and was interred at the New Calton Cemetery.[2] The grave is in a concealed location on the north face of the north-most vault against the east wall.