Pritchard's archaeological reputation began to be established by his excavations at a site called el-Jib (1956–1962). He identified it as Gibeon by inscriptions on the Al Jib jar handles. He cataloged these in Hebrew Inscriptions and Stamps From Gibeon (1959), which included the first in-depth discussion of concentric-circle incisions on jar handles associated with LMLK seals. He explained the significance of his finds for a general audience in Gibeon: Where the Sun Stood Still (1962).
He followed (1964–1967) with excavations at Tell es-Sa'idiyeh, on the east bank in the Jordan Valley, Jordan, which revealed itself as a meeting place for disparate cultures during the transition in the late Bronze Age to the use of iron, which he connected to the influence of the Sea Peoples ("New evidence on the role of the Sea Peoples in Canaan at the Beginning of the Iron Age"), in The Role of the Phoenicians, 1968. His work was cut short by the 1967 Six-Day War.
His third and last major excavation at Sarafand, Lebanon (1969–1974) revealed the ancient Phoenician city of Sarepta. It was the first time a major Phoenician city situated in the Phoenician heartland had been fully excavated. His first findings were published in 1975: he described pottery workshops and kilns, artifacts of daily use and religious figurines, a shrine, numerous inscriptions that included some in Ugaritic, and a seal with the city's name that made the identification secure. His article, "Sarepta in history and tradition" in Understanding the Sacred Texts (1972) displays his characteristic research. His book Recovering Sarepta, an Ancient Phoenician City (1978) was written for general readers. In 1975 he published with Baruch A. Levine The Israelites, the 18th book in the Time-Life 20 vol. series The Emergence of Man.
Additional works included Archaeology and the Old Testament (1958), which traced the evolution of modern approaches to archaeology from the first excavations in the Holy Land; and Solomon and Sheba (1974), which separated fact from legend.