Jaime Rafael Perelló Borrás was born on September 14, 1973, in San Juan. He studied at the Santa Teresita Academy in Santurce where he was secretary of his class in 1992. Perelló then studied at the Interamerican University of Puerto Rico where he obtained a Bachelor's degree in Political Science in 1998.
In 2000, Perelló was appointed by José Aponte de la Torre, then Mayor of Carolina, as adviser for health reform. Concerned for the health crisis caused by the Navy bombardments in Vieques, Perelló and Aponte founded the Corporation Salud para Vieques, where he served as part of the Board of Directors.
The next year, Aponte asked him to work as special aide in charge of federal government affairs as well as serving as a liaison with mayors from Puerto Rico and the United States. In 2003, he was arrested people for performing civil disobedience on Vieques, serving 30 days in a federal prison (see United States Navy in Vieques, Puerto Rico).
In 2000 and 2004, Perelló ran for a District Representative's seat and lost against Epi Jimenez, Jr. for the 40th district of Carolina.
In 2012, Perelló led the team of candidates for representatives of the Popular Democratic Party to achieve a majority in the House of Representative of Puerto Rico.
His father Luis Perelló was executive assistant to Governor Rafael Hernández Colón in his first term. His mother Carmen Borrás was an insurance broker.