In 2015, Bruun Larsen signed for Borussia Dortmund from Lyngby.[4] On 15 March 2017, the club announced the extension of his contract until 2021.[5]
On 23 January 2018, Bruun Larsen joined VfB Stuttgart on a half-season loan deal.[6]
He scored his first goal for Borussia Dortmund in a 7–0 victory over 1. FC Nürnberg on 27 September 2018.[7]
TSG Hoffenheim
On 31 January 2020, TSG Hoffenheim announced the signing of Bruun Larsen on a four-and-a-half-year deal.[8]
Bruun Larsen signed for Belgian club Anderlecht on 23 January 2021. He agreed to a loan until the end of the season.[9]
On 27 July 2023, Bruun Larsen signed for newly-promoted Premier League team Burnley on a season-long loan deal.[10] On 21 May 2024, Burnley said it was working to make the loan permanent.[11]