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Isogenous group

Micrograph of hyaline cartilage containing isogenous groups.

An isogenous group (lat. "equal origin") is a cluster of up to eight chondrocytes[1] found in hyaline and elastic cartilage.[2]

Formation

Chondrocytes develop in the embryo from mesenchymal progenitor cells through a process known as chondrogenesis.[2][3] A chondrocyte can then undergo mitosis to form an isogenous group within its lacuna.[3][4]

Function

Isogenous groups differentiate into individual chondrocytes where they continue to produce and deposit extracellular matrix (ECM), lengthening the cartilage and increasing its diameter.[3][5] This is termed interstitial growth and is one of only two ways cartilage can grow.[4]

Cartoon representation of hyaline cartilage with isogenous groups.

See also

References

  1. ^ Nahian, Ahmed; Sapra, Amit (2021), "Histology, Chondrocytes", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32491508, retrieved 2021-11-28
  2. ^ a b Wheater's Functional Histology, 6th ed. Young, O'Dowd and Woodford.
  3. ^ a b c Leboffe, Michael J. (2013). "Chapter 5: Cartilage and Bone". A Photographic Atlas of Histology Second Edition. Morton Publishing. pp. 51–55. ISBN 978-161731-068-3.
  4. ^ a b Hall, Brian K. (2005), "Chapter 3: Cartilage", Bones and Cartilage: Developmental and Evolutionary Skeletal Biology, Elsevier, p. 35, ISBN 9780080454153, retrieved 2021-11-28
  5. ^ Asanbaeva, Anna; Masuda, Koichi; Thonar, Eugene J.-M. A.; Klisch, Stephen M.; Sah, Robert L. (2007). "Mechanisms of cartilage growth: Modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC". Arthritis & Rheumatism. 56 (1): 188–198. doi:10.1002/art.22298. ISSN 1529-0131. PMID 17195221.
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