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Isis is a goddess from the polytheistic pantheon of Ancient Egypt.

Isis or ISIS may also refer to:

ISIS, an acronym for the unrecognized state sometimes known as the Islamic State of Iraq and Syria.

Computing

ISIS (operating system), used on the Intel 8085 processor
CDS ISIS, a non-numerical information storage and retrieval software developed by UNESCO
Image and Scanner Interface Specification
Infinitely Scalable Information Storage, a video storage system from Avid Technology
Integrated Software for Imagers and Spectrometers, software to process data collected by NASA planetary missions
IS-IS or ISIS, a network routing protocol
ISIS/Draw, a chemistry modelling program
Softcard or Isis Mobile Wallet, a mobile payment system
Unity ISIS, a storage device
Integrated Scientific Information System, software programs including the MDL Chime plug-in
ISIS, a variant of the JOSS programming language

Independent Schools Information Service, part of the Independent Schools Council
Isis Innovation or Oxford University Innovation, a British technology transfer company
ISIS Equity Partners or Livingbridge, a private equity firm headquartered in London
HM Prison Isis, a young offenders institution in London
Institute for Science and International Security, an American non-governmental institution
Institute for the Scientific Investigation of Sexuality or the Family Research Institute, an American anti-gay organization
Institute for the Secularisation of Islamic Society, an American organization
International Society for Iranian Studies or the Association for Iranian Studies, a U.S.-based academic organization
International Society for the Interdisciplinary Study of Symmetry
International Species Information System or Species360, a zoo and aquarium software development and data-sharing organization
ISIS Group or the Adara Group, an international development organisation dealing with issues of human trafficking
Isis-Urania Temple, a religious group
Innovative Solutions In Space, a Dutch aerospace company

Isis (lunar crater)
42 Isis, an asteroid
Electoral district of Isis, a former state electoral district in Queensland, Australia
Shire of Isis, a former local government area in Queensland, Australia
Port of Isis, Bulhar
Isis Highway, a highway in Queensland, Australia
The Isis, the upper part of the River Thames in Oxford, UK
- Isis Bridge, across the River Thames near Oxford, UK
Isis River, Queensland, a locality in Queensland, Australia
Isis River (Queensland), a river in Queensland, Australia
Isis, Ohio, an unincorporated community
Isis Temple, a prominence in the Grand Canyon in the United States

42 Isis, an asteroid
Isis (genus), a soft coral genus
ISIS (satellite), a series of Canadian satellites
Hippotion isis, a species of moth
International Studies of Infarct Survival, a set of clinical trials
ISIS neutron source, a pulsed neutron and muon source
Isis, a former research reactor at CEA Saclay
ISIS, alternate abbreviation for IS☉IS, an instrument aboard the Parker Solar Probe spacecraft to Earth's Sun

Integrated Sensor is Structure, a project to develop an airship for intelligence use
Integrated standby instrument system, a backup instrument display for aircraft
ISIS Drive or International Splined Interface Standard, a bicycle bottom bracket interface specification
Morris Isis, a car by Morris Motors from 1929 to 1931 and a car from the British Motor Corporation in the 1950s
Toyota Isis, a seven-seat large MPV