On 29 January 2000, he was appointed as the first executive vice president of Venezuela. Eleven months later, on December 26, with the majority vote of the National Assembly, he was appointed as Attorney General of the Republic, a position he held until November 2007.[1]
In March 2018, Panama sanctioned 55 public officials, including Isaías Rodríguez.[4]
During 2018 until 2019 he worked as the Venezuelan Ambassador in Italy. During the 2019 Venezuelan presidential crisis, Rodríguez expressed concern for US sanctions on Venezuela.[5] According to him, these sanctions prevent him to pay his workers and the Embassy debt has risen to about 9 million euros.[5] Rodríguez resigned to his job as ambassador in May due to the tight budget of the embassy.[5] In his resignation letter published on Twitter, he expressed support for "Maduro's battle". He writes that he leaves "without money" and that Italian banks have "closed its doors" to him.[5]