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Intectin

Intectin is a Ly-6 family protein which is anchored to glycosylphosphatidylinositol on intestinal epithelial cells. Intectin has been shown to maintain the integrity of the intestinal wall by inducing apoptosis of intestinal epithelial cells upon exposure to dietary palmitic acid.[1] Mice treated with the prebiotic oligofructose showed improved intestinal homeostasis as indicated by increased intectin.[2]

References

  1. ^ Kitazawa H, Nishihara T, Nambu T, Nishizawa H, Iwaki M, Fukuhara A, Kitamura T, Matsuda M, Shimomura I (2004). "Intectin, a novel small intestine-specific glycosylphosphatidylinositol-anchored protein, accelerates apoptosis of intestinal epithelial cells". Journal of Biological Chemistry. 279 (41): 42867–42874. doi:10.1074/jbc.M408047200. PMID 15292182.
  2. ^ Everard A, Lazarevic V, Gaïa N, Johansson M, Ståhlman M, Backhed F, Delzenne NM, Schrenzel J, François P, Cani PD (2014). "Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity". The ISME Journal. 8 (10): 2116–2130. Bibcode:2014ISMEJ...8.2116E. doi:10.1038/ismej.2014.45. PMC 4163056. PMID 24694712.


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